Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Saliva and Serum Immune Responses in Apical Periodontitis
University of Helsiki, Finland.
University of Helsiki, Finland.
University of Oulu, Finland.
Karolinska Institutet, Sweden.
Show others and affiliations
2019 (English)In: Journal of clinical medicine, ISSN 2077-0383, Vol. 8, no 6, article id 889Article in journal (Refereed) Published
Abstract [en]

Apical periodontitis is an inflammatory reaction at the apex of an infected tooth. Its microbiota resembles that of marginal periodontitis and may induce local and systemic antibodies binding to bacteria- and host-derived epitopes. Our aim was to investigate the features of the adaptive immune response in apical periodontitis. The present Parogene cohort (n = 453) comprises patients with cardiac symptoms. Clinical and radiographic oral examination was performed to diagnose apical and marginal periodontitis. A three-category endodontic lesion score was designed. Antibodies binding to the bacteria- and host-derived epitopes were determined from saliva and serum, and bacterial compositions were examined from saliva and subgingival samples. The significant ORs (95% CI) for the highest endodontic scores were observed for saliva IgA and IgG to bacterial antigens (2.90 (1.01-8.33) and 4.91 (2.48-9.71)/log10 unit), saliva cross-reacting IgG (2.10 (1.48-2.97)), serum IgG to bacterial antigens (4.66 (1.22-10.1)), and Gram-negative subgingival species (1.98 (1.16-3.37)). In a subgroup without marginal periodontitis, only saliva IgG against bacterial antigens associated with untreated apical periodontitis (4.77 (1.05-21.7)). Apical periodontitis associates with versatile adaptive immune responses against both bacterial- and host-derived epitopes independently of marginal periodontitis. Saliva immunoglobulins could be useful biomarkers of oral infections including apical periodontitis-a putative risk factor for systemic diseases.

Place, publisher, year, edition, pages
Basel, Switzerland: MDPI, 2019. Vol. 8, no 6, article id 889
Keywords [en]
adaptive immunity, antibody, apical periodontitis, saliva, serum
National Category
Clinical Medicine
Research subject
Immunology
Identifiers
URN: urn:nbn:se:umu:diva-161062DOI: 10.3390/jcm8060889ISI: 000475349300133PubMedID: 31234349OAI: oai:DiVA.org:umu-161062DiVA, id: diva2:1331640
Available from: 2019-06-27 Created: 2019-06-27 Last updated: 2019-08-12Bibliographically approved

Open Access in DiVA

fulltext(2536 kB)72 downloads
File information
File name FULLTEXT01.pdfFile size 2536 kBChecksum SHA-512
965bc2cd4d474bea5239427a0d1bcab80f9bcfd24f06633e78afb6b23c88a44509b7407a542cb975ddc23a67530d92ce60e24876359964db826560aeba388dfb
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Johansson, Anders
By organisation
Department of Odontology
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 72 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 86 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf