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Increasing the accuracy of glioblastoma subtypes: Factoring in the tumor's cell of origin
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology.
2019 (English)In: MOLECULAR & CELLULAR ONCOLOGY, ISSN 2372-3556, Vol. 6, no 1, article id e1302907Article in journal (Refereed) Published
Abstract [en]

The transcriptional classification of glioblastoma has proven to be a complex issue. In the absence of strong correlations between underlying genomic lesions and transcriptional subtype, there is a need to systematically understand the origins of the glioblastoma subtypes. A recent integrated analysis of data from both mouse models and patient-derived cells supports that the glioblastoma's cell of origin is important in shaping transcriptional diversity and tumor cell malignancy.

Place, publisher, year, edition, pages
2019. Vol. 6, no 1, article id e1302907
Keywords [en]
Cell of origin, data integration, glioblastoma classification, plasticity, systems biology
National Category
Cancer and Oncology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-388041DOI: 10.1080/23723556.2017.1302907ISI: 000470299200001PubMedID: 30788413OAI: oai:DiVA.org:uu-388041DiVA, id: diva2:1331578
Available from: 2019-06-27 Created: 2019-06-27 Last updated: 2019-06-27Bibliographically approved

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