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Introducing a New Algorithm for Classification of Etiology in Studies on Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children for Enhanced Diagnostics Study
South Gen Hosp, Sachs Children & Youth Hosp, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden;Karolinska Insitutet, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
South Gen Hosp, Sachs Children & Youth Hosp, Hjalmar Cederstroms Gata 14, S-11861 Stockholm, Sweden.
Astrid Lindgren Childrens Hosp, Stockholm, Sweden.
Karolinska Inst, Dept Med, Div Infect Dis, Stockholm, Sweden;Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden.
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2019 (English)In: JMIR Research Protocols, ISSN 1929-0748, E-ISSN 1929-0748, Vol. 8, no 4, article id e12705Article in journal (Refereed) Published
Abstract [en]

Background: There is a need to better distinguish viral infections from antibiotic-requiring bacterial infections in children presenting with clinical community-acquired pneumonia (CAP) to assist health care workers in decision making and to improve the rational use of antibiotics.

Objective: The overall aim of the Trial of Respiratory infections in children for ENhanced Diagnostics (TREND) study is to improve the differential diagnosis of bacterial and viral etiologies in children aged below 5 years with clinical CAP, by evaluating myxovims resistance protein A (MxA) as a biomarker for viral CAP and by evaluating an existing (multianalyte point-of-care antigen detection test system [mariPOC respi] ArcDia International Oy Ltd.) and a potential future point-of-care test for respiratory pathogens.

Methods: Children aged 1 to 59 months with clinical CAP as well as healthy, hospital-based, asymptomatic controls will be included at a pediatric emergency hospital in Stockholm, Sweden. Blood (analyzed for MxA and C-reactive protein) and nasopharyngeal samples (analyzed with real-time polymerase chain reaction as the gold standard and antigen-based mariPOC respi test as well as saved for future analyses of a novel recombinase polymerase amplification-based point-of-care test for respiratory pathogens) will be collected. A newly developed algorithm for the classification of CAP etiology will be used as the reference standard.

Results: A pilot study was performed from June to August 2017. The enrollment of study subjects started in November 2017. Results are expected by the end of 2019.

Conclusions: The findings from the TREND study can be an important step to improve the management of children with clinical CAP.

Place, publisher, year, edition, pages
JMIR PUBLICATIONS, INC , 2019. Vol. 8, no 4, article id e12705
Keywords [en]
pneumonia, child, preschool, respiratory tract infections, microbiological techniques, diagnostic tests, routine
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-387222DOI: 10.2196/12705ISI: 000466496800030PubMedID: 31025954OAI: oai:DiVA.org:uu-387222DiVA, id: diva2:1329876
Funder
EU, FP7, Seventh Framework Programme, ALF-20150503EU, FP7, Seventh Framework Programme, HMT-20150818EU, FP7, Seventh Framework Programme, 615458Available from: 2019-06-25 Created: 2019-06-25 Last updated: 2019-06-25Bibliographically approved

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