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Probiotika som komplement vid Helicobacter pylori-eradikering: En litteraturstudie
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2019 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [sv]

Bakgrund: Infektion med Helicobacter pylori är vanligt förekommande världen över. Forskning pekar på att låg socioekonomisk status, trångboddhet och dålig hygien tycks gynna smitta med Helicobacter pylori. Helicobacter pylori infekterar magsäckens och/eller tolvfingertarmens slemhinna, vilket kan resultera i magsår och gastrit. Därmed bör behandling sättas in efter påvisad infektion med Helicobacter pylori, för att förebygga risken att magsäckscancer utvecklas. Behandling vid infektion orsakad av Helicobacter pylori innefattar oftast trippelterapibehandling bestående av protonpumpshämmare samt två olika antibiotikum. Forskning pekar på att probiotika har positiva effekter i behandling mot Helicobacter pylori.

Syfte: Uppsatsen syftar till att undersöka och redogöra för om trippelterapibehandling i kombination med probiotika är en effektivare behandling hos patienter infekterade med Helicobacter pylori, än enbart trippelterapibehandling.

Metod: Studien är designad som en litteraturstudie. I studien granskades sex stycken vetenskapliga, randomiserade, kliniskt prövade originalartiklar. Litteratursökningen genomfördes i databasen PubMed.

Resultat: Fyra av studierna visade en signifikant skillnad mellan interventionsgruppen som tilldelats probiotika + trippelterapibehandling, och kontrollgruppen som enbart tilldelats trippelterapibehandling.

Slutsats: Slutsatsen är att probiotika kombinerat med trippelterapibehandling är något effektivare än enbart trippelterapibehandling. För- och efterbehandling med probiotika i samband med en trippelterapibehandling gav störst effekt. Ytterligare studier krävs för att säkerställa effekten av probiotika vid en trippelterapibehandling.

Abstract [en]

Background: Being infected by Helicobacter pylori is very common all around the world. Research indicates that low socioeconomic status, overcrowding and bad hygiene most likely increases the risk of being infected by Helicobacter pylori. Helicobacter pylori infects the stomach and/or duodenal mucosa, which can result in a gastric ulcer and gastritis. Therefore, treatment should be instituted directly after Helicobacter pylori has been detected, to reduce the risk of developing gastric cancer. Treatment for a infection caused by Helicobacter pylori often involves a triple therapy treatment consisting of a proton-pump inhibitor and two different types of antibiotics. Research indicates that probiotics could have positive effects regarding treatment against Helicobacter pylori.

Aim: The aim of this study is to examine if triple therapy treatment in combination with probiotics is a more effective treatment for patients infected by Helicobacter pylori, than with triple therapy treatment alone.

Method: This study is designed as a literature study. Six different scientific, randomized, clinically tested original articles were examined. The literature search was conducted in the database PubMed.

Result: There was a significant difference in four studies between the intervention group, which was assigned probiotics + triple therapy, and the control group, which was assigned only triple therapy treatment.

Conclusion: The conclusion is that probiotics combined with triple therapy treatment is somewhat more effective than triple therapy treatment alone. A treatment with probiotics before and after a treatment with triple therapy treatment gave the largest effect. Further studies are needed to ensure the effect of probiotics with a triple therapy treatment.

Place, publisher, year, edition, pages
2019.
Keywords [en]
Antibiotics, Bifidobacterium, eradication, Helicobacter pylori, Lactobacillus, peptic ulcer, probiotics
Keywords [sv]
Antibiotika, Bifidobakterier, eradikering, Helicobacter pylori, Lactobaciller, magsår, probiotika
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-85808OAI: oai:DiVA.org:lnu-85808DiVA, id: diva2:1329520
Subject / course
Biomedicine
Educational program
Health Science Programme with Specialisation in Bio Sciences, 180 credits
Presentation
, Kalmar
Supervisors
Examiners
Available from: 2019-06-24 Created: 2019-06-24 Last updated: 2019-06-24Bibliographically approved

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