Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
University Hospital Gasthuisberg, Leuven, Belgium; University of Leuven, Herestraat 49, Leuven, 3000, Belgium.
University Hospital S.Orsola, Bologna, Italy.
Centro Médico Teknon, Barcelona, Spain.
County Durham and Darlington NHS Trust, Durham, United Kingdom.
Show others and affiliations
2019 (English)In: BMC Gastroenterology, ISSN 1471-230X, E-ISSN 1471-230X, Vol. 19, no 1, article id 69Article in journal (Refereed) Published
Abstract [en]

Background: Irritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK). Methods: An observational, one year retrospective-prospective (6 months each) study of patients diagnosed in the last five years with IBS-C (Rome III criteria) and moderate to severe disease at inclusion (IBS Symptom Severity Scale score = 175). The primary objective was to assess the direct cost to European healthcare systems. Results: Five hundred twenty-five patients were included, 60% (range: 43.1-78.8%) suffered from severe IBS-C. During follow-up 11.1-24.0% of patients had a hospitalisation/emergency room (ER) visit, median stay range: 1.5-12.0 days and 41.1-90.4% took prescription drugs for IBS-C. 21.4-50.8% of employed patients took sick leave (mean: 11.6-64.1 days). The mean annual direct cost to the healthcare systems was €937.1- €2108.0. The total direct cost (combined costs to healthcare systems and patient) for IBS-C was €1421.7-€2487.1. Conclusions: IBS-C is not a life-threatening condition; however, it has large impact on healthcare systems and society. Direct and indirect costs for moderate to severe IBS-C were high with the largest direct cost driver being hospitalisations/ER visits. © 2019 The Author(s).

Place, publisher, year, edition, pages
BioMed Central Ltd. , 2019. Vol. 19, no 1, article id 69
Keywords [en]
Economic analysis; Europe; Healthcare resource utilisation; IBS; IBS-C
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:liu:diva-158060DOI: 10.1186/s12876-019-0985-1ISI: 000467407000001PubMedID: 31064345Scopus ID: 2-s2.0-85065501524OAI: oai:DiVA.org:liu-158060DiVA, id: diva2:1329142
Note

Funding agencies:This study and all data analyses were funded in full by Almirall, S.A. The preparation of this paper was funded by Almirall, S.A and Allergan International.

Available from: 2019-06-24 Created: 2019-06-24 Last updated: 2019-11-04

Open Access in DiVA

fulltext(965 kB)4 downloads
File information
File name FULLTEXT01.pdfFile size 965 kBChecksum SHA-512
1cea54334f18f17bc6135194f813d4ec5eeb9d674141f1891be4c9c02d43304e39253842a0c0d9698df058fbe8a5850a37ae811e99c9a70c1424f6c1a577a6a4
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Walter, Susanna
By organisation
Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Gastroentorology
In the same journal
BMC Gastroenterology
Gastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar
Total: 4 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 7 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf