Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk
Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld, Australia.
Natl Cerebral & Cardiovasc Ctr Res Inst, Dept Cell Biol, Osaka, Japan.
Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld, Australia.
Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld, Australia.
Show others and affiliations
2019 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e42881Article in journal (Refereed) Published
Abstract [en]

Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature. The Hippo pathway and effectors Yap and Taz control organ growth and regulate morphogenesis and cellular proliferation. Yap and Taz control angiogenesis but a role in lymphangiogenesis remains to be fully elucidated. Here we show that YAP displays dynamic changes in lymphatic progenitors and Yap1 is essential for lymphatic vascular development in zebrafish. Maternal and Zygotic (MZ) yap1 mutants show normal specification of lymphatic progenitors, abnormal cellular sprouting and reduced numbers of lymphatic progenitors emerging from the cardinal vein during lymphangiogenesis. Furthermore, Yap1 is indispensable for Vegfc-induced proliferation in a transgenic model of Vegfc overexpression. Paracrine Vegfc-signalling ultimately increases nuclear YAP in lymphatic progenitors to control lymphatic development. We thus identify a role for Yap in lymphangiogenesis, acting downstream of Vegfc to promote expansion of this vascular lineage.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2019. Vol. 8, article id e42881
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-385565DOI: 10.7554/eLife.42881ISI: 000467896500001PubMedID: 31038457OAI: oai:DiVA.org:uu-385565DiVA, id: diva2:1327082
Available from: 2019-06-19 Created: 2019-06-19 Last updated: 2019-06-19Bibliographically approved

Open Access in DiVA

fulltext(10024 kB)30 downloads
File information
File name FULLTEXT01.pdfFile size 10024 kBChecksum SHA-512
b2c7eebc9b63210bc0a3fa227e15fe863cbed37fe683423c937e89c0f49c516c4a9ad12645af82eb98dcd3d114c3fa65b73f317c1047d029779a5e87a3ae5d04
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Koltowska, KatarzynaMochizuki, NaokiHogan, Benjamin M.
By organisation
Vascular Biology
In the same journal
eLIFE
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 30 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 28 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf