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Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
RefLab ApS, Denmark; Univ Copenhagen, Denmark.
Charite Univ Med Berlin, Germany.
Univ Southampton, England.
Otto von Guericke Univ, Germany; Skin Ctr MDZ, Germany.
Show others and affiliations
2019 (English)In: Clinical and Translational Allergy, ISSN 2045-7022, E-ISSN 2045-7022, Vol. 9, article id 24Article, review/survey (Refereed) Published
Abstract [en]

Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position paper from the task force provides an overview of the current use of SMD in the investigation of the pathogenesis of chronic inflammatory skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis, and in studies of cutaneous events during type 1 hypersensitivity reactions. Furthermore, this paper covers drug hypersensitivity, UVB-induced- and neurogenic inflammation, and drug penetration investigated by SMD. The aim of this paper is to encourage the use of SMD and to make the technique easily accessible by providing an overview of methodology and applications, supported by standardized operating procedures for SMD in vivo and ex vivo.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 9, article id 24
Keywords [en]
Microdialysis; Cutaneous; Inflammation; Interstitial; Dermal
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:liu:diva-157221DOI: 10.1186/s13601-019-0262-yISI: 000464857200001PubMedID: 31007896OAI: oai:DiVA.org:liu-157221DiVA, id: diva2:1324351
Note

Funding Agencies|EAACI

Available from: 2019-06-13 Created: 2019-06-13 Last updated: 2019-10-31

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Division of Cell BiologyFaculty of Medicine and Health SciencesDepartment of Dermatology and Venerology
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