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Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions
San Francisco State Univ, CA 94132 USA; Vanderbilt Univ, TN 37240 USA.
San Francisco State Univ, CA 94132 USA; Nankai Univ, Peoples R China; Nankai Univ, Peoples R China.
San Francisco State Univ, CA 94132 USA.
San Francisco State Univ, CA 94132 USA; Guangxi Univ, Peoples R China.
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2019 (English)In: Light: Science & Applications, ISSN 2095-5545, E-ISSN 2047-7538, Vol. 8, article id 31Article in journal (Refereed) Published
Abstract [en]

Osmotic conditions play an important role in the cell properties of human red blood cells (RBCs), which are crucial for the pathological analysis of some blood diseases such as malaria. Over the past decades, numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes. Here, we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions. Specifically, we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions, where the strength of the optical nonlinearity increases with osmotic pressure on the cells. This tunable nonlinearity is attributed to optical forces, particularly the forward-scattering and gradient forces. Interestingly, in aged blood samples (with lysed cells), a notably different nonlinear behavior is observed due to the presence of free hemoglobin. We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations. Our work on light self-guiding through scattering bio-soft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis.

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CHINESE ACAD SCIENCES, CHANGCHUN INST OPTICS FINE MECHANICS AND PHYSICS , 2019. Vol. 8, article id 31
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URN: urn:nbn:se:liu:diva-157260DOI: 10.1038/s41377-019-0142-1ISI: 000463971300003PubMedID: 30886708OAI: oai:DiVA.org:liu-157260DiVA, id: diva2:1323835
Note

Funding Agencies|NIH (USA); NSF (USA); ARO (USA); National Key R&D Program of China [2017YFA0303800]; National Natural Science Foundation of China [91750204, 11504184, 11604058]; NSERC; Canada Research Chair Program (Canada); Government of the Russian Federation through the ITMO Fellowship and Professorship Program [074-U 01]; 1000 Talents Sichuan Program in China

Available from: 2019-06-12 Created: 2019-06-12 Last updated: 2019-10-30

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