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The Effect of Microdialysis Catheter Insertion on Glutamate and Serotonin Levels in Masseter Muscle in Patients with Myofascial Temporomandibular Disorders and Healthy Controls
Malmo Univ, Sweden.
Malmo Univ, Sweden; Umea Univ, Sweden.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Public Dental Health Care, Center for Oral Rehabilitation Norrköping. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
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2019 (English)In: Diagnostics (Basel), ISSN 2075-4418, Vol. 9, no 1, article id 14Article in journal (Refereed) Published
Abstract [en]

Myofascial temporomandibular disorders (TMD) are the most common cause of chronic pain in the orofacial region. Microdialysis has been used to study metabolic changes in the human masseter muscle. The insertion of the microdialysis probe causes acute tissue trauma that could affect the metabolic milieu and thereby influence the results when comparing healthy subjects to those with TMD. This study aimed to investigate the levels of serotonin and glutamate during the acute tissue trauma period in healthy subjects and in patients with TMD. Microdialysis was carried out in 15 patients with TMD and 15 controls, and samples were collected every 20 min during a period of 140 min. No significant alterations of serotonin or glutamate were observed over the 2 h period for the healthy subjects. For the TMD group, a significant decrease in serotonin was observed over time (p amp;lt; 0.001), followed by a significant increase between 120 and 140 min (p amp;lt; 0.001). For glutamate, a significant reduction was observed at 40 min compared to baseline. The results showed that there was a spontaneous increase of serotonin 2 h after the insertion of the catheter in patients with TMD. In conclusion, the results showed that there are differences in the masseter muscle levels of serotonin and glutamate during acute nociception in patients with myofascial TMD compared to healthy subjects.

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 9, no 1, article id 14
Keywords [en]
microdialysis; myofascial temporomandibular disorders; serotonin; glutamate; chronic pain
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-157275DOI: 10.3390/diagnostics9010014ISI: 000464204000001PubMedID: 30678220Scopus ID: 2-s2.0-85066418195OAI: oai:DiVA.org:liu-157275DiVA, id: diva2:1323806
Note

Funding Agencies|Swedish Research Council [K2015-99X-21874-05-04]; AFA Insurance [Dnr-140341]; forsknings-ALF of County council of Ostergotland [LIO-608021, LIO-700931]; Ake Wiberg foundation

Available from: 2019-06-12 Created: 2019-06-12 Last updated: 2019-10-29Bibliographically approved

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Dawson, AndreasGerdle, BjörnGhafouri, Bijar
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