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Baseline serum folate, vitamin B12 and the risk of prostate and breast cancer using data from the Swedish AMORIS cohort
Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Res Oncol Translat Oncol & Urol Res TOUR, 3rd Floor,Bermondsey Wing, London SE1 9RT, England.
Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Res Oncol Translat Oncol & Urol Res TOUR, 3rd Floor,Bermondsey Wing, London SE1 9RT, England.
Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Res Oncol Translat Oncol & Urol Res TOUR, 3rd Floor,Bermondsey Wing, London SE1 9RT, England;Reg Canc Ctr, Uppsala, Sweden.ORCID iD: 0000-0001-7181-7083
Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden;AstraZeneca, Global Med Affairs, Med Evidence & Observat Res, Molndal, Sweden.
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2019 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 30, no 6, p. 603-615Article in journal (Refereed) Published
Abstract [en]

Purpose: The roles of folate and vitamin B12 in prostate cancer (PCa) or breast cancer (BC) development are unclear. We investigated their roles using the prospective Swedish Apolipoprotein MOrtality RISk (AMORIS) study.

Methods: 8,783 men and 19,775 women with vitamin B12 and folate serum measurements were included. Their associations with PCa and BC risk categories were evaluated using Cox proportional hazards regression.

Results: During mean follow-up of 13years, 703 men developed PCa. There was an inverse association between folate>32nmol/L and high-risk PCa [hazard ratio (HR) 0.12, 95% confidence interval (CI) 0.02-0.90], and a positive association between folate<5nmol/L and metastatic PCa (HR 5.25, 95% CI 1.29-21.41), compared with folate 5-32nmol/L. No associations with vitamin B12 were found. 795 women developed BC during mean follow-up of 14years. When restricting to the fasting population, there was a positive association between folate>32nmol/L and BC (HR 1.47, 95% CI 1.06-2.04).

Conclusion: High folate levels may protect against PCa and low folate levels may increase risk of metastatic PCa. High fasting folate levels may be associated with an increased BC risk. Vitamin B12 was not found to be linked with risk of PCa or BC. Longitudinal studies with serum and dietary information could help define new prevention targets and add information on the role of folate fortification.

Place, publisher, year, edition, pages
SPRINGER , 2019. Vol. 30, no 6, p. 603-615
Keywords [en]
Prostate cancer (PCa), Breast cancer (BC), Vitamin B12, Folate, Severity
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-384996DOI: 10.1007/s10552-019-01170-6ISI: 000467796500005PubMedID: 31020446OAI: oai:DiVA.org:uu-384996DiVA, id: diva2:1323092
Funder
Swedish Cancer SocietyAvailable from: 2019-06-11 Created: 2019-06-11 Last updated: 2019-06-11Bibliographically approved

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