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Extracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis
Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).ORCID iD: 0000-0001-7049-6978
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2019 (English)In: Journal of Experimental Botany, ISSN 0022-0957, E-ISSN 1460-2431, Vol. 70, no 7, p. 2199-2210Article in journal (Refereed) Published
Abstract [en]

During plant vascular development, xylem tracheary elements (TEs) form water-conducting, empty pipes by genetically regulated cell death. Cell death is prevented from spreading to non-TEs by unidentified intercellular mechanisms, downstream of METACASPASE9 (MC9)-mediated regulation of autophagy in TEs. Here, we identified differentially abundant extracellular peptides in vascular-differentiating wild-type and MC9-down-regulated Arabidopsis cell suspensions. A peptide named Kratos rescued the abnormally high ectopic non-TE death resulting from either MC9 knockout or TE-specific overexpression of the ATG5 autophagy protein during experimentally induced vascular differentiation in Arabidopsis cotyledons. Kratos also reduced cell death following mechanical damage and extracellular ROS production in Arabidopsis leaves. Stress-induced but not vascular non-TE cell death was enhanced by another identified peptide, named Bia. Bia is therefore reminiscent of several known plant cell death-inducing peptides acting as damage-associated molecular patterns. In contrast, Kratos plays a novel extracellular cell survival role in the context of development and during stress response.

Place, publisher, year, edition, pages
Oxford University Press, 2019. Vol. 70, no 7, p. 2199-2210
Keywords [en]
Arabidopsis, autophagy, cell death, peptide, peptidomics, programmed cell death, stress response, vascular development, xylem
National Category
Botany
Identifiers
URN: urn:nbn:se:umu:diva-159631DOI: 10.1093/jxb/erz021ISI: 000467901600018PubMedID: 30753577OAI: oai:DiVA.org:umu-159631DiVA, id: diva2:1321952
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Bio4EnergyAvailable from: 2019-06-10 Created: 2019-06-10 Last updated: 2019-11-06Bibliographically approved

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Escamez, SachaWillems, PatrickWrzaczek, MichaelTuominen, Hannele
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