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Salmonella and Reactive Oxygen Species: A Love-Hate Relationship
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
2019 (English)In: Journal of Innate Immunity, ISSN 1662-811X, E-ISSN 1662-8128, Vol. 11, no 3, p. 216-226Article, review/survey (Refereed) Published
Abstract [en]

Salmonella enterica represents an enterobacterial species including numerous serovars that cause infections at, or initiated at, the intestinal epithelium. Many serovars also act as facultative intracellular pathogens with a tropism for phagocytic cells. These bacteria not only survive in phagocytes but also undergo de facto replication therein. Phagocytes, through the activities of phagocyte NADPH-dependent oxidase and inducible nitric oxide synthase, are very proficient in converting molecular oxygen to reactive oxygen (ROS) and nitrogen species (RNS). These compounds represent highly efficient effectors of the innate immune defense. Salmonella is by no means resistant to these effectors, which may stand in contrast to the host niches chosen. To cope with this paradox, these bacteria rely on an array of detoxification and repair systems. Combination these systems allows for a high enough tolerance to ROS and RNS to enable establishment of infection. In addition, salmonella possesses protein factors that have the potential to dampen the infection-associated inflammation, which evidently results in a reduced exposure to ROS and RNS. This review attempts to summarize the activities and strategies by which salmonella tries to cope with ROS and RNS and how the bacterium can make use of these innate defense factors.

Place, publisher, year, edition, pages
S. Karger, 2019. Vol. 11, no 3, p. 216-226
Keywords [en]
Reactive oxygen species, Reactive nitrogen species, Salmonella enterica, Phagocyte
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-159642DOI: 10.1159/000496370ISI: 000467678500004PubMedID: 30943492OAI: oai:DiVA.org:umu-159642DiVA, id: diva2:1319718
Available from: 2019-06-03 Created: 2019-06-03 Last updated: 2019-06-03Bibliographically approved

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Rhen, Mikael
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