Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Thyroid Function and Dysfunction in Relation to 16 Cardiovascular Diseases: A Mendelian Randomization Study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden. (Epihubben)ORCID iD: 0000-0003-0118-0341
Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. (Epihubben)ORCID iD: 0000-0003-2815-1217
Show others and affiliations
2019 (English)In: Circulation: Genomic and Precision Medicine, ISSN 2574-8300, Vol. 12, no 3, p. 121-126, article id e002468Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Subclinical thyroid dysfunction, defined as thyroidstimulating hormone levels outside the reference range with normal free thyroxine levels in asymptomatic patients, is associated with alterations in cardiac hemodynamics. We used Mendelian randomization to assess the role of thyroid dysfunction for cardiovascular disease (CVD).

METHODS: Single-nucleotide polymorphisms associated with thyroid function were identified from a genome-wide association meta-analysis in up to 72 167 individuals. Data for genetic associations with CVD were obtained from meta-analyses of genome-wide association studies of atrial fibrillation (n= 537 409 individuals), coronary artery disease (n= 184 305 individuals), and ischemic stroke (n= 438 847) as well as from the UK Biobank (n= 367 703 individuals).

RESULTS: Genetically predicted thyroid-stimulating hormone levels and hyperthyroidism were statistically significantly associated with atrial fibrillation but no other CVDs at the Bonferroni-corrected level of significance (P< 7.8x10-4). The odds ratios of atrial fibrillation were 1.15 (95% CI, 1.11-1.19; P= 2.4x10-14) per genetically predicted 1 SD decrease in thyroid-stimulating hormone levels and 1.05 (95% CI, 1.03-1.08; P= 5.4x10-5) for genetic predisposition to hyperthyroidism. Genetically predicted free thyroxin levels were not statistically significantly associated with any CVD.

CONCLUSIONS: This Mendelian randomization study supports evidence for a causal association of decreased thyroid-stimulating hormone levels in the direction of a mild form of hyperthyroidism with an increased risk of atrial fibrillation but no other CVDs.

Place, publisher, year, edition, pages
2019. Vol. 12, no 3, p. 121-126, article id e002468
Keywords [en]
atrial fibrillation, cardiovascular disease, hormones, hyperthyroidism, thyrotropin
National Category
Cardiac and Cardiovascular Systems Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-383883DOI: 10.1161/CIRCGEN.118.002468ISI: 000466741300009PubMedID: 30702347OAI: oai:DiVA.org:uu-383883DiVA, id: diva2:1319110
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2018-00123Swedish Research Council, 2016-01042Wellcome trust, 204623/Z/16/ZAvailable from: 2019-05-29 Created: 2019-05-29 Last updated: 2019-05-29Bibliographically approved

Open Access in DiVA

fulltext(189 kB)43 downloads
File information
File name FULLTEXT01.pdfFile size 189 kBChecksum SHA-512
4d8c4bc11913b058e9d500817d9d0e18483a314898b8fa091a7c8a9adae75cd0deb8685276a4ac34602f1d7b1f9e2f7a602c8ad9994fb9ddfe9824031a131a50
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Larsson, Susanna C.Michaëlsson, Karl
By organisation
Orthopaedics
Cardiac and Cardiovascular SystemsEndocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 43 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 39 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf