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Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study
Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.ORCID iD: 0000-0003-0118-0341
Univ Cambridge, Stroke Res Grp, Dept Clin Neurosci, Cambridge, England.
Univ Cambridge, MRC Biostat Unit, Cambridge, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Fdn IRCCS Ist Neurol Carlo Besta, Dept Cerebrovasc Dis, Milan, Italy.
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2019 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 92, no 9, p. E944-E950Article in journal (Refereed) Published
Abstract [en]

Objective To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.

Methods Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).

Results In standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI-] 0.69-0.89; p = 1.3 x 10-4) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; p = 1.6 x 10-4) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.

Conclusions This study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.

Place, publisher, year, edition, pages
2019. Vol. 92, no 9, p. E944-E950
National Category
Neurology Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-383885DOI: 10.1212/WNL.0000000000007001ISI: 000465408500016PubMedID: 30804065OAI: oai:DiVA.org:uu-383885DiVA, id: diva2:1319080
Available from: 2019-05-29 Created: 2019-05-29 Last updated: 2019-05-29Bibliographically approved

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