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Ribonucleotides in mitochondrial DNA
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. (Andrei Chabes)
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).ORCID iD: 0000-0003-1708-8259
2019 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 593, no 13, p. 1554-1565Article, review/survey (Refereed) Published
Abstract [en]

The incorporation of ribonucleotides (rNMPs) into DNA during genome replication has gained substantial attention in recent years and has been shown to be a significant source of genomic instability. Studies in yeast and mammals have shown that the two genomes, the nuclear DNA (nDNA) and the mitochondrial DNA (mtDNA), differ with regard to their rNMP content. This is largely due to differences in rNMP repair - whereas rNMPs are efficiently removed from the nuclear genome, mitochondria lack robust mechanisms for removal of single rNMPs incorporated during DNA replication. In this minireview, we describe the processes that determine the frequency of rNMPs in the mitochondrial genome and summarise recent findings regarding the effect of incorporated rNMPs on mtDNA stability and function.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 593, no 13, p. 1554-1565
Keywords [en]
dNTP, genome stability, mitochondrial DNA, ribonucleotides
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-159088DOI: 10.1002/1873-3468.13440ISI: 000477916000012PubMedID: 31093968Scopus ID: 2-s2.0-85066896219OAI: oai:DiVA.org:umu-159088DiVA, id: diva2:1316377
Funder
Swedish Research CouncilSwedish Cancer SocietySwedish Society for Medical Research (SSMF)
Note

Special Issue: Krakow Special Issue

Available from: 2019-05-17 Created: 2019-05-17 Last updated: 2019-09-06Bibliographically approved

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