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Striking parallels between carotid body glomus cell and adrenal chromaffin cell development
Univ Cambridge, Dept Physiol Dev & Neurosci, Anat Bldg,Downing St, Cambridge CB2 3DY, England;John Radcliffe Hosp, Weatherall Inst Mol Med, Headley Way, Oxford OX3 9DS, England;Univ Cape Town, Dept Mol & Cell Biol, Cape Town, South Africa;Univ Cape Town, Fac Hlth Sci, Dept Anat, Div Cell Biol, Cape Town, South Africa.ORCID iD: 0000-0003-2613-6216
Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden;Med Univ Vienna, Ctr Brain Res, A-1090 Vienna, Austria.
Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.ORCID iD: 0000-0002-8781-9769
Univ Cambridge, Dept Physiol Dev & Neurosci, Anat Bldg,Downing St, Cambridge CB2 3DY, England.
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2018 (English)In: Developmental Biology, ISSN 0012-1606, E-ISSN 1095-564X, Vol. 444, no Suppl. 1, p. S308-S324Article in journal (Refereed) Published
Abstract [en]

Carotid body glomus cells mediate essential reflex responses to arterial blood hypoxia. They are dopaminergic and secrete growth factors that support dopaminergic neurons, making the carotid body a potential source of patient-specific cells for Parkinson's disease therapy. Like adrenal chromaffin cells, which are also hypoxia-sensitive, glomus cells are neural crest-derived and require the transcription factors Ascl1 and Phox2b; otherwise, their development is little understood at the molecular level. Here, analysis in chicken and mouse reveals further striking molecular parallels, though also some differences, between glomus and adrenal chromaffin cell development. Moreover, histology has long suggested that glomus cell precursors are 'emigres' from neighbouring ganglia/nerves, while multipotent nerve-associated glial cells are now known to make a significant contribution to the adrenal chromaffin cell population in the mouse. We present conditional genetic lineage-tracing data from mice supporting the hypothesis that progenitors expressing the glial marker proteolipid protein 1, presumably located in adjacent ganglia/nerves, also contribute to glomus cells. Finally, we resolve a paradox for the 'emigre' hypothesis in the chicken - where the nearest ganglion to the carotid body is the nodose, in which the satellite glia are neural crest-derived, but the neurons are almost entirely placode-derived - by fate-mapping putative nodose neuronal 'emigres' to the neural crest.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2018. Vol. 444, no Suppl. 1, p. S308-S324
Keywords [en]
Carotid body glomus cells, Adrenal chromaffin cells, Neural crest, Schwann cell precursors, Nodose neurons
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-383040DOI: 10.1016/j.ydbio.2018.05.016ISI: 000464483000026PubMedID: 29807017OAI: oai:DiVA.org:uu-383040DiVA, id: diva2:1314268
Funder
EU, European Research Council, REP-647844-1EU, European Research Council, 232675Swedish Research CouncilSwedish Research CouncilWellcome trust, 086804/Z/08/ZWellcome trust, 082556Wellcome trust, 097420/Z/11/ZGerman Research Foundation (DFG), So251/3-1Åke Wiberg FoundationAvailable from: 2019-05-08 Created: 2019-05-08 Last updated: 2019-05-08Bibliographically approved

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Hockman, DoritKaucka, MarketaSock, ElisabethWaithe, DominicFranck, Marina Christina MikaelaReese, Jeffrey
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