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Behandling med Valeriana eller Zolpidem för bättre sömn hos personer med insomni?
Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
2019 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesisAlternative title
Treatment with Valerian or Zolpidem for better sleep in people with insomnia? (English)
Abstract [sv]

Sömnstörningar beror på störningar av de faktorer som normalt leder till sömn, där individen har svårigheter att somna och upplever då sömnlösa nätter. Sömnstörningar är vanligt förekommande i befolkningen och förekommer i olika former där insomni (sömnlöshet) är den typ som detta arbete har baserats på. Insomni är ett tillstånd som kan behandlas med både det växtbaserade läkemedlet Valeriana och det bensodiazepinliknande läkemedlet Zolpidem. Valeriana (vänderot) är en flerårig ört där dess jordstam används för produktion av läkemedel. Valeriana förekommer i olika beredningar, har använts vid behandling av insomningsbesvär under flera hundra år och verkar ha en lugnande/hypnotisk effekt. Valeriana säljs även receptfritt. Zolpidem ingår i gruppen hypnotika och är ett sömnmedel som har snabbverkande effekt. Läkemedlet verkar på liknande sätt som bensodiazepiner, där den kemiska strukturen skiljer dessa läkemedel åt. Syftet med detta examensarbete är att undersöka vilket av dessa 2 läkemedel som mest effektivt förbättrar sömnen hos personer med insomni, genom att separat jämföra läkemedlen med placebo. Vidare bedöms om skillnader finns mellan läkemedlens biverkningar. Arbetet baserades på 6 relevanta studier som hittades genom sökning på databasen PubMed samt OneSearch via Linnéuniversitets bibliotek.

Slutsatsen av examensarbetet är att Zolpidem mer effektivt förbättrar sömnen hos personer med sömnlöshet, när Zolpidem och Valeriana var sig har jämförts med placebo. Inga av läkemedlen hade några allvarliga biverkningar, läkemedlen hade också liknande biverkningar med undantag för enstaka sällsynta incidenter hos Zolpidem. Zolpidem hade en bibehållen effekt med tiden. Zolpidem rekommenderas för behandling av personer med sömnlöshet eftersom detta läkemedel behandlar symtomen mer effektivt.

Abstract [en]

Sleep disorders come from disruptions in factors that precedes sleep, where the individual has an inability to fall asleep and thus experiences sleepless nights.Sleep disorders are a common occurrence and come in different shapes where insomnia is the type this project will focus on. Insomnia is a condition that can be treated with both the herbal medicine Valerian and the drug Zolpidem that is similar to benzodiazepine.Valerian is a perennial herb where its earth stem is used in drug manufacturing. Valerian comes in different preparations, has been used in treatment of sleep difficulties during centuries and seems to have a hypnotic effect. Valerian is also a prescription free drug. Side effects due to the use of Valerian may be gastrointestinal symptoms such as nausea and abdominal pain. Overall side effects from use of this herbal are rare.Zolpidem is a hypnotic with a fast-acting effect. The drug works in similar ways to benzodiazepine but the chemical structure differs from benzodiazepine. Side effects that may occur include amnesia and sleep walking behavior. Increased anxiety, restlessness and mood swings are common side effects from use of Zolpidem.The purpose of this project is to investigate which of these two drugs are more effective at improving sleep in people with insomnia, by separately comparing the drugs to placebo. Further on assessments were made regarding the differences between the drugs side effects. This project is based on six relevant studies found through the database PubMed and OneSearch through the library of university of Linnaeus.

Results of the studies showed that Valerian did not improve sleep compared to placebo in people with insomnia. Zolpidem, however, improved sleep in these people compared to placebo. No serious adverse events occurred with either of the drugs.This project concludes that Zolpidem is more effective at improving sleep in insomniacs, when Zolpidem and Valerian were individually compared to placebo. The drugs had similar adverse events, and none of them were serious. Zolpidem did however have a few rare incidents regarding adverse events. Zolpidem had a retained effect over time. Zolpidem is recommended for treating insomniacs since this drug has displayed greater efficacy in treating the symptoms.

Place, publisher, year, edition, pages
2019. , p. 35
Keywords [sv]
Behandling med Zolpidem, Behandling med Valeriana, Insomni
National Category
Medical and Health Sciences Natural Sciences
Identifiers
URN: urn:nbn:se:lnu:diva-82467OAI: oai:DiVA.org:lnu-82467DiVA, id: diva2:1314208
Subject / course
Pharmacy
Educational program
Bachelor of Science Programme in Pharmacy, 180 credits
Supervisors
Examiners
Available from: 2019-05-21 Created: 2019-05-07 Last updated: 2019-05-21Bibliographically approved

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