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Synaptic vesicle protein 2A as a potential biomarker in synaptopathies
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2019 (English)In: Molecular and Cellular Probes, ISSN 1044-7431, E-ISSN 1095-9327, Vol. 97, p. 34-42Article in journal (Refereed) Published
Abstract [en]

Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 97, p. 34-42
Keywords [en]
Biomarkers, Position emission tomography, SV2A, Synaptopathies
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-382939DOI: 10.1016/j.mcn.2019.02.001ISI: 000472239000004PubMedID: 30796959OAI: oai:DiVA.org:uu-382939DiVA, id: diva2:1314037
Funder
Knut and Alice Wallenberg FoundationMagnus Bergvall FoundationSwedish Research CouncilEU, European Research CouncilAvailable from: 2019-05-07 Created: 2019-05-07 Last updated: 2019-08-07Bibliographically approved

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