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Interaction between Shift Work and Established Coronary Risk Factors
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
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2019 (English)In: International Journal of Occupational and Environmental Medicine, ISSN 2008-6520, E-ISSN 2008-6814, Vol. 10, no 2, p. 57-65, article id 1466Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work.

OBJECTIVE: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction.

METHODS: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis.

RESULTS: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38).

CONCLUSION: Shift work and some established coronary risk factors have significant interactions.

Place, publisher, year, edition, pages
IJOEM , 2019. Vol. 10, no 2, p. 57-65, article id 1466
Keywords [en]
Cardiovascular diseases, Epidemiology, Risk factors, Shift work schedule, Synergy
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:umu:diva-158677DOI: 10.15171/ijoem.2019.1466ISI: 000466504000003PubMedID: 31041922OAI: oai:DiVA.org:umu-158677DiVA, id: diva2:1313949
Available from: 2019-05-07 Created: 2019-05-07 Last updated: 2019-05-20Bibliographically approved

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