Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Role of Microsystems Integration Towards Point-of-Care Clozapine Treatment Monitoring in Schizophrenia.
Institute for Systems Research, University of Maryland, College Park, MD, USA.
Show others and affiliations
2018 (English)In: IEEE sensors letters, ISSN 2475-1472, Vol. 2, no 1, article id 5500304Article in journal (Refereed) Published
Abstract [en]

We present a perspective on microsystems integration aspects for concurrent cellular and molecular sensing in a lab-on-a-chip device. While of interest for a range of applications, very few - narrowly focused - examples of such devices can be found in the literature. Here, we approach the challenge from a systems level, considering sensor integration both in parallel and in series. Our study is specifically geared toward schizophrenia treatment, where concurrent blood monitoring of the antipsychotic clozapine and white blood cells could lead to improved treatment outcomes. We evaluate the critical system components for either design, namely plasma skimming (parallel) and in-blood clozapine detection (series). We find that plasma skimming is infeasible, but for the first time demonstrate direct detection of clozapine in whole blood. With a corresponding series-integrated microsystem, we finally demonstrate downstream white blood cell analysis on the same samples using impedance cytometry. We thus present the first lab-on-a-chip device capable of label- and reagent-free concurrent sensing of cellular and molecular markers.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2018. Vol. 2, no 1, article id 5500304
Keywords [en]
clozapine, impedance cytometry, microsystems integration, plasma skimming, white blood cells
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-250559DOI: 10.1109/LSENS.2017.2782883PubMedID: 29308452OAI: oai:DiVA.org:kth-250559DiVA, id: diva2:1308058
Funder
NIH (National Institute of Health), R56-MH105571
Note

QC 20190528

Available from: 2019-04-30 Created: 2019-04-30 Last updated: 2019-05-28Bibliographically approved

Open Access in DiVA

fulltext(352 kB)15 downloads
File information
File name FULLTEXT01.pdfFile size 352 kBChecksum SHA-512
7377efe8fcd12401689b13e8400f4107ca59e5aa1d8f097c078bdc7a4ea2829b7315a0ae2d8ffeab425361f278c649bcfc650d7c425a40280e8454e4b463a0c9
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Winkler, Thomas
Other Medical Engineering

Search outside of DiVA

GoogleGoogle Scholar
Total: 15 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 17 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf