Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Determinants of time to institutionalisation and related healthcare and societal costs in a community-based cohort of patients with Alzheimer's disease dementia
Eli Lilly & Co Ltd, Lilly Res Ctr, Windlesham, Surrey, England.
Univ Barcelona, CIBERSAM, Barcelona, Spain.
Eli Lilly & Co Ltd, Lilly Res Ctr, Windlesham, Surrey, England.
Eli Lilly & Co Ltd, Lilly Res Ctr, Windlesham, Surrey, England.
Show others and affiliations
2019 (English)In: European Journal of Health Economics, ISSN 1618-7598, E-ISSN 1618-7601, Vol. 20, no 3, p. 343-355Article in journal (Refereed) Published
Abstract [en]

Objectives: To examine the costs of caring for community-dwelling patients with Alzheimer’s disease (AD) dementia in relation to the time to institutionalisation.

Methods: GERAS was a prospective, non-interventional cohort study in community-dwelling patients with AD dementia and their caregivers in three European countries. Using identified factors associated with time to institutionalisation, models were developed to estimate the time to institutionalisation for all patients. Estimates of monthly total societal costs, patient healthcare costs and total patient costs (healthcare and social care together) prior to institutionalisation were developed as a function of the time to institutionalisation.

Results: Of the 1495 patients assessed at baseline, 307 (20.5%) were institutionalised over 36 months. Disease severity at baseline [based on Mini-Mental State Examination (MMSE) scores] was associated with risk of being institutionalised during follow up (p < 0.001). Having a non-spousal informal caregiver was associated with a faster time to institutionalisation (944 fewer days versus having a spousal caregiver), as was each one-point worsening in baseline score of MMSE, instrumental activities of daily living and behavioural disturbance (67, 50 and 30 fewer days, respectively). Total societal costs, total patient costs and, to a lesser extent, patient healthcare-only costs were associated with time to institutionalisation. In the 5 years pre-institutionalisation, monthly total societal costs increased by more than £1000 (€1166 equivalent for 2010) from £1900 to £3160 and monthly total patient costs almost doubled from £770 to £1529.

Conclusions: Total societal costs and total patient costs rise steeply as community-dwelling patients with AD dementia approach institutionalisation.

Place, publisher, year, edition, pages
2019. Vol. 20, no 3, p. 343-355
Keywords [en]
Alzheimer's disease, Societal costs, Institutionalisation, Predictors, Caregiver
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-382653DOI: 10.1007/s10198-018-1001-3ISI: 000463662800003PubMedID: 30178148OAI: oai:DiVA.org:uu-382653DiVA, id: diva2:1307795
Funder
Eli Lilly and CompanyAvailable from: 2019-04-29 Created: 2019-04-29 Last updated: 2019-04-29Bibliographically approved

Open Access in DiVA

fulltext(856 kB)73 downloads
File information
File name FULLTEXT01.pdfFile size 856 kBChecksum SHA-512
707acc174e3fb6f4eda7ea5768c28c7b8f690c7718bff0c003630c2bb18d722202606cda37cf8d3a60d3042f6a60ec3f73851808978b428b86b0d0890287d31d
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wimo, Anders
By organisation
Centre for Research and Development, Gävleborg
In the same journal
European Journal of Health Economics
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 73 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 105 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf