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Exclusive Enteral Nutrition: Clinical Effects and Changes in Mucosal Cytokine Profile in Pediatric New Inflammatory Bowel Disease
Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden;Soder Sjukhuset, Sachs Children & Youth Hosp, Dept Gastroenterol, S-11883 Stockholm, Sweden.ORCID iD: 0000-0002-5453-6754
Karolinska Univ Hosp, Clin Immunol & Transfus Med, S-14157 Huddinge, Sweden;Karolinska Inst, Dept Med, S-14157 Huddinge, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Karolinska Inst, Dept Womens & Childrens Hlth, S-17177 Stockholm, Sweden.
Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden;Soder Sjukhuset, Sachs Children & Youth Hosp, Dept Gastroenterol, S-11883 Stockholm, Sweden.
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2019 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, no 2, article id 414Article in journal (Refereed) Published
Abstract [en]

Exclusive Enteral Nutrition (EEN) is the first-line treatment in children with Crohn's disease (CD) for induction of remission. However, the mode of action remains conjectural. The aim of this study was to investigate whether the effect of EEN is paralleled by changes in the mucosal cytokine profiles (MCP). Twelve children with new onset inflammatory bowel disease (IBD) received induction treatment with a polymeric EEN. We assessed clinical, endoscopic and histologic scoring before and after EEN. Twelve colonic cytokines were analyzed by Polymerase Chain Reaction (PCR) in six of the IBD patients at onset and after EEN as well as in six non-IBD control children at the diagnostic colonoscopy. Twelve children completed 6 weeks of EEN, except from one child who completed 4 weeks. At the control colonoscopy, 83% were in complete clinical remission. Changes were found in the MCPs of individual patients after EEN. In particular, children with IBD showed significantly higher values of Interleukin (IL)-12 (p = 0.008) and IL-23 (p = 0.02) compared to non-IBD controls at the diagnostic colonoscopy. Furthermore, an overall change in proinflammatory cytokines was noted in the IBD-group after treatment. Further studies are warranted to understand the role of EEN in MCP.

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 11, no 2, article id 414
Keywords [en]
exclusive enteral nutrition, children, IBD, remission, mucosal cytokines
National Category
Gastroenterology and Hepatology
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URN: urn:nbn:se:uu:diva-380501DOI: 10.3390/nu11020414ISI: 000460829700205PubMedID: 30781421OAI: oai:DiVA.org:uu-380501DiVA, id: diva2:1306427
Available from: 2019-04-23 Created: 2019-04-23 Last updated: 2019-04-23Bibliographically approved

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