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Population Genetic and Functional Analysis of a cis-Regulatory Polymorphism in the Drosophila melanogaster Metallothionein A gene
Ludwig Maximilians Univ Munchen, Fac Biol, Div Evolutionary Biol, Grosshaderner Str 2, D-82152 Planegg Martinsried, Germany.
Ludwig Maximilians Univ Munchen, Fac Biol, Div Evolutionary Biol, Grosshaderner Str 2, D-82152 Planegg Martinsried, Germany.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Ludwig Maximilians Univ Munchen, Fac Biol, Div Evolutionary Biol, Grosshaderner Str 2, D-82152 Planegg Martinsried, Germany.
Ludwig Maximilians Univ Munchen, Fac Biol, Div Evolutionary Biol, Grosshaderner Str 2, D-82152 Planegg Martinsried, Germany.
2019 (English)In: Genes, ISSN 2073-4425, E-ISSN 2073-4425, Vol. 10, no 2, article id 147Article in journal (Refereed) Published
Abstract [en]

Although gene expression can vary extensively within and among populations, the genetic basis of this variation and the evolutionary forces that maintain it are largely unknown. In Drosophila melanogaster, a 49-bp insertion/deletion (indel) polymorphism in the Metallothionein A (MtnA) gene is associated with variation in MtnA expression and oxidative stress tolerance. To better understand the functional and evolutionary significance of this polymorphism, we investigated it in several worldwide populations. In a German population, the deletion was present at a high and stable frequency over multiple seasons and years, and was associated with increased MtnA expression. There was, however, no evidence that the polymorphism was maintained by overdominant, seasonally fluctuating, or sexually antagonistic selection. The deletion was rare in a population from the species' ancestral range in sub-Saharan Africa and is likely the result of non-African admixture, suggesting that it spread to high frequency following the species' out-of-Africa expansion. Using data from a North American population, we found that the deletion was associated with MtnA expression and tolerance to oxidative stress induced by menadione sodium bisulfite. Our results are consistent with the deletion being selectively favored in temperate populations due to the increased MtnA expression and oxidative stress tolerance that it confers.

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 10, no 2, article id 147
Keywords [en]
gene expression, cis-regulation, deletion, indel, untranslated region, oxidative stress, population genetics, Drosophila melanogaster
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-380504DOI: 10.3390/genes10020147ISI: 000460742800076PubMedID: 30769915OAI: oai:DiVA.org:uu-380504DiVA, id: diva2:1306415
Funder
German Research Foundation (DFG)Available from: 2019-04-23 Created: 2019-04-23 Last updated: 2019-04-23Bibliographically approved

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