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HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Department of Zoology, Government Emerson College, Multan, Pakistan.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing, China.
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2019 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 2, article id e0212648Article in journal (Refereed) Published
Abstract [en]

Senile plaques are well-known hallmarks of Alzheimer's Diseases (AD). However, drugs targeting tangles of the protein tau and plaques of beta-amyloid have no significant effect on disease progression, and the studies on the underlying mechanism of AD remain in high demand. Growing evidence supports the protective role of senile plaques in local inflammation driven by S100A9. We herein demonstrate that oleic acid (OA) micelles interact with hen egg white lysozyme (HEWL) and promote its amyloid formation. Consequently, SH-SY5Y cell line and mouse neural stem cells are rescued from OA toxicity by co-aggregation of OA and HEWL. Using atomic force microscopy in combination with fluorescence microscopy, we revealed that HEWL forms round-shaped aggregates in the presence of OA micelles instead of protofibrils of HEWL alone. These HEWL amyloids act as a sink for toxic OA micelles and their co-aggregate form large clumps, suggesting a protective function in amyloid and OA cytotoxicity.

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PUBLIC LIBRARY SCIENCE , 2019. Vol. 14, no 2, article id e0212648
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Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
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URN: urn:nbn:se:umu:diva-157530DOI: 10.1371/journal.pone.0212648ISI: 000459709100105PubMedID: 30794655OAI: oai:DiVA.org:umu-157530DiVA, id: diva2:1301310
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01Bibliographically approved

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Liu, YonggangMorozova-Roche, LudmillaZhang, Ce
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