Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease
Consejo Nacl Invest Cient & Tecn, IIBBA, Fdn Inst Leloir, Lab Amyloidosis & Neurodegenerat,CABA, Buenos Aires, DF, Argentina.
UBA, Fac Med, Ctr Neuropsiquiatria Neurol Conducta CENFCON, CABA, Buenos Aires, DF, Argentina;UBA, CABA, Fac Med, Dept Ciencias Fisiol UAII, Buenos Aires, DF, Argentina;Hosp Interzonal Gen Agudos Eva Peron, Buenos Aires, DF, Argentina.
UBA, Fac Med, Ctr Neuropsiquiatria Neurol Conducta CENFCON, CABA, Buenos Aires, DF, Argentina;UBA, CABA, Fac Med, Dept Ciencias Fisiol UAII, Buenos Aires, DF, Argentina.
UBA, CABA, Inst Invest Med Lanari, Lab Bioquim Mol,Fac Med, Buenos Aires, DF, Argentina.
Show others and affiliations
2019 (English)In: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 9, article id 55Article in journal (Refereed) Published
Abstract [en]

Rare coding variants in TREM2, PLCG2, and ABI3 were recently associated with the susceptibility to Alzheimer's disease (AD) in Caucasians. Frequencies and AD-associated effects of variants differ across ethnicities. To start filling the gap on AD genetics in South America and assess the impact of these variants across ethnicity, we studied these variants in Argentinian population in association with ancestry. TREM2 (rs143332484 and rs75932628), PLCG2 (rs72824905), and ABI3 (rs616338) were genotyped in 419 AD cases and 486 controls. Meta-analysis with European population was performed. Ancestry was estimated from genome-wide genotyping results. All variants show similar frequencies and odds ratios to those previously reported. Their association with AD reach statistical significance by meta-analysis. Although the Argentinian population is an admixture, variant carriers presented mainly Caucasian ancestry. Rare coding variants in TREM2, PLCG2, and ABI3 also modulate susceptibility to AD in populations from Argentina, and they may have a European heritage.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2019. Vol. 9, article id 55
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-379282DOI: 10.1038/s41398-019-0394-9ISI: 000459833200009PubMedID: 30705288OAI: oai:DiVA.org:uu-379282DiVA, id: diva2:1296316
Available from: 2019-03-14 Created: 2019-03-14 Last updated: 2019-03-14Bibliographically approved

Open Access in DiVA

fulltext(821 kB)65 downloads
File information
File name FULLTEXT01.pdfFile size 821 kBChecksum SHA-512
63e47dedb033cd0bf57b99b4cb3b69adbe30cf99e4b377cf9a0418d304c68dee88a5fcbdc913eaf4b12b758011a2563da903860632d6c1465e074ffa1c4e2f88
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hoffmann, PerBullido, MariaIngelsson, MartinLambert, Jean-Charles
By organisation
Geriatrics
In the same journal
Translational Psychiatry
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 65 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 62 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf