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Functional Diversity of AAA plus Protease Complexes in Bacillus subtilis
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Department of Regulation in Infection Biology, Max Planck Institute for Infection Biology, Berlin, Germany; Humboldt University, Berlin, Germany.ORCID iD: 0000-0002-0254-0778
2017 (English)In: Frontiers in Molecular Biosciences, ISSN 2296-889X, Vol. 4, article id 44Article, review/survey (Refereed) Published
Abstract [en]

Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2017. Vol. 4, article id 44
Keywords [en]
AAA plus protease complexes, Hsp100/Clp proteins, Bacillus subtilis, protein quality control, chaperones, regulatory proteolysis, McsB, adaptor proteins
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-157321DOI: 10.3389/fmolb.2017.00044ISI: 000455311400009PubMedID: 28748186Scopus ID: 2-s2.0-85039775261OAI: oai:DiVA.org:umu-157321DiVA, id: diva2:1296247
Funder
Göran Gustafsson Foundation for Research in Natural Sciences and MedicineGerman Research Foundation (DFG)Available from: 2019-03-14 Created: 2019-03-14 Last updated: 2019-03-14Bibliographically approved

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