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The Intriguing Evolutionary Journey of Enteroinvasive E-coli (EIEC) toward Pathogenicity
Sapienza Univ Roma, Dept Biol & Biotechnol C Darwin, Ist Pasteur Italia, Rome, Italy.
European Union, Dept Vet Publ Hlth & Food Safety, Reference Lab Escherichia Coli, Ist Super Sanita, Rome, Italy.
Sapienza Univ Roma, Dept Biol & Biotechnol C Darwin, Ist Pasteur Italia, Rome, Italy;Uppsala Univ, Sci Life Lab, Dept Med Biochem & Microbiol, Uppsala, Sweden.
European Union, Dept Vet Publ Hlth & Food Safety, Reference Lab Escherichia Coli, Ist Super Sanita, Rome, Italy.
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2017 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 8, article id 2390Article, review/survey (Refereed) Published
Abstract [en]

Among the intestinal pathogenic Escherichia coli, enteroinvasive E. coli (EIEC) are a group of intracellular pathogens able to enter epithelial cells of colon, multiplicate within them, and move between adjacent cells with a mechanism similar to Shigella, the ethiological agent of bacillary dysentery. Despite EIEC belong to the same pathotype of Shigella, they neither have the full set of traits that define Shigella nor have undergone the extensive gene decay observed in Shigella. Molecular analysis confirms that EIEC are widely distributed among E. coli phylogenetic groups and correspond to bioserotypes found in many E. coli serogroups. Like Shigella, also in EIEC the critical event toward a pathogenic life-style consisted in the acquisition by horizontal gene transfer of a large F-type plasmid (pINV) containing the genes required for invasion, intracellular survival, and spreading through the intestinal mucosa. In Shigella, the ample gain in virulence determinants has been counteracted by a substantial loss of functions that, although important for the survival in the environment, are redundant or deleterious for the life inside the host. The pathoadaptation process that has led Shigella to modify its metabolic profile and increase its pathogenic potential is still in infancy in EIEC, although maintenance of some features typical of E. coli might favor their emerging relevance as intestinal pathogens worldwide, as documented by recent outbreaks in industrialized countries. In this review, we will discuss the evolution of EIEC toward Shigella-like invasive forms going through the epidemiology, including the emergence of new virulent strains, their genome organization, and the complex interactions they establish with the host.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2017. Vol. 8, article id 2390
Keywords [en]
pathogenic E. coli, enteroinvasive E. coli (EIEC), Shigella, bacterial evolution, emerging EIEC
National Category
Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-376984DOI: 10.3389/fmicb.2017.02390ISI: 000417046000002PubMedID: 29259590OAI: oai:DiVA.org:uu-376984DiVA, id: diva2:1294640
Available from: 2019-03-08 Created: 2019-03-08 Last updated: 2019-03-08Bibliographically approved

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