Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Genome expansion of an obligate parthenogenesis-associated Wolbachia poses an exception to the symbiont reduction model
Vrije Univ Amsterdam, Dept Ecol Sci, Amsterdam, Netherlands.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution.
Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands;Leiden Univ, Leiden Genome Technol Ctr, Med Ctr, Leiden, Netherlands.
Leiden Univ, Leiden Genome Technol Ctr, Med Ctr, Leiden, Netherlands.
Show others and affiliations
2019 (English)In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 20, article id 106Article in journal (Refereed) Published
Abstract [en]

Background: Theory predicts that dependency within host-endosymbiont interactions results in endosymbiont genome size reduction. Unexpectedly, the largest Wolbachia genome was found in the obligate, parthenogenesis-associated wFol. In this study, we investigate possible processes underlying this genome expansion by comparing a re-annotated wFol genome to other Wolbachia genomes. In addition, we also search for candidate genes related to parthenogenesis induction (PI).

Results: Within wFol, we found five phage WO regions representing 25.4% of the complete genome, few pseudogenized genes, and an expansion of DNA-repair genes in comparison to other Wolbachia. These signs of genome conservation were mirrored in the wFol host, the springtail F. candida, which also had an expanded DNA-repair gene family and many horizontally transferred genes. Across all Wolbachia genomes, there was a strong correlation between gene numbers of Wolbachia strains and their hosts. In order to identify genes with a potential link to PI, we assembled the genome of an additional PI strain, wLcla. Comparisons between four PI Wolbachia, including wFol and wLcla, and fourteen non-PI Wolbachia yielded a small set of potential candidate genes for further investigation.

Conclusions: The strong similarities in genome content of wFol and its host, as well as the correlation between host and Wolbachia gene numbers suggest that there may be some form of convergent evolution between endosymbiont and host genomes. If such convergent evolution would be strong enough to overcome the evolutionary forces causing genome reduction, it would enable expanded genomes within long-term obligate endosymbionts.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 20, article id 106
Keywords [en]
Folsomia candida, Leptopilina clavipes, wFol, wLcla, Parthenogenesis induction
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-378385DOI: 10.1186/s12864-019-5492-9ISI: 000458370700001PubMedID: 30727958OAI: oai:DiVA.org:uu-378385DiVA, id: diva2:1293764
Available from: 2019-03-05 Created: 2019-03-05 Last updated: 2019-03-05Bibliographically approved

Open Access in DiVA

fulltext(1755 kB)34 downloads
File information
File name FULLTEXT01.pdfFile size 1755 kBChecksum SHA-512
4842c09a45732bd3f01c964461b2a2b5df4e87c94ee9d70f46867f79ee2d80f418515eb7614eb22aa2ea39c2017e626ebf2f3f390d5fdeca7556f047db44fbc2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Klasson, Lisa
By organisation
Molecular Evolution
In the same journal
BMC Genomics
Evolutionary Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 34 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 52 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf