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Low Molecular Mass Myocardial Hyaluronan in Human Hypertrophic Cardiomyopathy
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
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2019 (English)In: Cells, ISSN 2073-4409, Vol. 8, no 2, article id 97Article in journal (Refereed) Published
Abstract [en]

During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the development of cardiac hypertrophy and fibrosis. The aim of this study was to investigate hyaluronan metabolism in cardiac tissue from patients with hypertrophic cardiomyopathy in relation to cardiac growth. NMR and qRT-PCR analysis of human cardiac tissue from hypertrophic cardiomyopathy patients and healthy control hearts showed dysregulated glucose and hyaluronan metabolism in the patients. Gas phase electrophoresis revealed a higher amount of low molecular mass hyaluronan and larger cardiomyocytes in cardiac tissue from patients with hypertrophic cardiomyopathy. Histochemistry showed high concentrations of hyaluronan around individual cardiomyocytes in hearts from hypertrophic cardiomyopathy patients. Experimentally, we could also observe accumulation of low molecular mass hyaluronan in cardiac hypertrophy in a rat model. In conclusion, the development of hypertrophic cardiomyopathy with increased glucose metabolism affected both hyaluronan molecular mass and amount. The process of regulating cardiomyocyte size seems to involve fragmentation of hyaluronan.

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 8, no 2, article id 97
Keywords [en]
GEMMA, glucose, hyaluronan, hypertrophic cardiomyopathy, metabolomics
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-156750DOI: 10.3390/cells8020097ISI: 000460896000019PubMedID: 30699940OAI: oai:DiVA.org:umu-156750DiVA, id: diva2:1291824
Available from: 2019-02-26 Created: 2019-02-26 Last updated: 2019-04-04Bibliographically approved

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