Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)
Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Univ Bergen, Core Facil Metabol, Jonas Lies Veg 87, N-5021 Bergen, Norway.
Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Inst Biol 2, Str Le Grazie 8, I-37134 Verona, Italy.
Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Inst Biol 2, Str Le Grazie 8, I-37134 Verona, Italy.
Haukeland Hosp, Dept Occupat Med, Jonas Lies Vei 65, N-5021 Bergen, Norway;Univ Bergen, Ctr Int Hlth, Jekteviksbakken 31, N-5009 Bergen, Norway.ORCID iD: 0000-0003-3269-8354
Show others and affiliations
2019 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 120, p. 29-34Article in journal (Refereed) Published
Abstract [en]

Objectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes. Study design: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. Main outcome measures: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). Results: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years. Conclusions: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2019. Vol. 120, p. 29-34
Keywords [en]
Hormone replacement therapy (HRT), Lung function, Menopause, Reproductive aging, Sex hormones
National Category
Respiratory Medicine and Allergy Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-376811DOI: 10.1016/j.maturitas.2018.11.007ISI: 000456223000005PubMedID: 30583761OAI: oai:DiVA.org:uu-376811DiVA, id: diva2:1291065
Funder
EU, Horizon 2020Available from: 2019-02-22 Created: 2019-02-22 Last updated: 2019-12-19Bibliographically approved

Open Access in DiVA

fulltext(1070 kB)91 downloads
File information
File name FULLTEXT01.pdfFile size 1070 kBChecksum SHA-512
a6797e22d6f6f53ad2d2b117127bd6bf6b1fcfe46d8a727691def296677659a9b02014080a71f573bdf77eae58109570c692fdb660540df39ac0bb13ad1d61d3
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Johannessen, AneDharmage, Shyamali C.Gullon Blanco, Jose AntonioJogi, RainLindberg, EvaSchlunssen, Vivi
By organisation
Lung- allergy- and sleep research
In the same journal
Maturitas
Respiratory Medicine and AllergyObstetrics, Gynecology and Reproductive Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 91 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 160 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf