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Shared heritability and functional enrichment across six solid cancers
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2019 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 431Article in journal (Refereed) Published
Abstract [en]

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 10, article id 431
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-156600DOI: 10.1038/s41467-018-08054-4ISI: 000456696700007PubMedID: 30683880OAI: oai:DiVA.org:umu-156600DiVA, id: diva2:1290438
Funder
NIH (National Institute of Health)Wellcome trust
Note

Errata: Xia Jiang, Hilary K. Finucane,...Sara Lindström. Publisher Correction to "Shared heritability and functional enrichment across six solid cancers" [Nature Communications 10 (2019), Article Number 431]. Nature Communications 10 (2019), Article Number 4386. DOI: 10.1038/s41467-019-12095-8

Available from: 2019-02-20 Created: 2019-02-20 Last updated: 2019-11-13Bibliographically approved

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