Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Where do all the subtypes go?: Temporal dynamics of H8-H12 influenza A viruses in waterfowl
Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39182 Kalmar, Sweden;Peter Doherty Inst Infect & Immun, WHO Collaborating Ctr Reference & Res Influenza, 792 Elizabeth St, Melbourne, Vic 3000, Australia.ORCID iD: 0000-0002-5629-0196
Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39182 Kalmar, Sweden;Lund Univ, Dept Biol, Ecol Bldg, S-22362 Lund, Sweden.
Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, SE-39182 Kalmar, Sweden.
J Craig Venter Inst, Dept Infect Dis, Rockville, MD USA.
Show others and affiliations
2018 (English)In: Virus Evolution, ISSN 0042-725X, E-ISSN 2281-1605, Vol. 4, no 2, article id vey025Article in journal (Refereed) Published
Abstract [en]

Influenza A virus (IAV) is ubiquitous in waterfowl. In the northern hemisphere IAV prevalence is highest during the autumn and coincides with a peak in viral subtype diversity. Although haemagglutinin subtypes H1-H12 are associated with waterfowl hosts, subtypes H8-H12 are detected very infrequently. To better understand the role of waterfowl in the maintenance of these rare subtypes, we sequenced H8-H12 viruses isolated from Mallards (Anas platyrhynchos) from 2002 to 2009. These rare viruses exhibited varying ecological and phylodynamic features. The Eurasian clades of H8 and H12 phylogenies were dominated by waterfowl sequences; mostly viruses sequenced in this study. H11, once believed to be a subtype that infected charadriiformes (shorebirds), exhibited patterns more typical of common virus subtypes. Finally, subtypes H9 and H10, which have maintained lineages in poultry, showed markedly different patterns: H10 was associated with all possible NA subtypes and this drove HA lineage diversity within years. Rare viruses belonging to subtypes H8-H12 were highly reassorted, indicating that these rare subtypes are part of the broader IAV pool. Our results suggest that waterfowl play a role in the maintenance of these rare subtypes, but we recommend additional sampling of non-traditional hosts to better understand the reservoirs of these rare viruses.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2018. Vol. 4, no 2, article id vey025
Keywords [en]
disease ecology, evolutionary genetics, influenza A, mallards, pathogen dynamics, subtype diversity
National Category
Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-376905DOI: 10.1093/ve/vey025ISI: 000456426800007PubMedID: 30151242OAI: oai:DiVA.org:uu-376905DiVA, id: diva2:1287792
Funder
Swedish Research Council, 2008-58Swedish Research Council, 2010-3067Swedish Research Council, 2011-48Swedish Research Council Formas, 2009-1220Swedish Research Council Formas, 2007-297Swedish Environmental Protection Agency, V-124-10Swedish Environmental Protection Agency, V-98-04Swedish Board of AgricultureAvailable from: 2019-02-12 Created: 2019-02-12 Last updated: 2019-02-12Bibliographically approved

Open Access in DiVA

fulltext(1839 kB)38 downloads
File information
File name FULLTEXT01.pdfFile size 1839 kBChecksum SHA-512
2640d4e1b1afdfc15ad9aeba9e3a7b0aa42485ea6704f238219fa08d772f2d1cdcccd3e6dcde79fbfc03426c15bbd389304f4fc5026de33f7044dcb14fc44f60
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wille, MichelleFouchier, Ron A. M.Pybus, Oliver G.Olsen, Björn
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
Virus Evolution
Microbiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 38 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 47 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf