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Architecture of the Mouse Brain Synaptome
Univ Edinburgh, Genes Cognit Program, Ctr Clin Brain Sci, Edinburgh EH16 4SB, Midlothian, Scotland.;UCL Inst Neurol, Queen Sq, London WC1N 3BG, England..
Univ Edinburgh, Genes Cognit Program, Ctr Clin Brain Sci, Edinburgh EH16 4SB, Midlothian, Scotland.;Univ Claude Bernard Lyon 1, Univ Lyon, Inst NeuroMyoGene, CNRS,UMR 5310,INSERM,U1217, F-69008 Lyon, France..
Univ Edinburgh, Genes Cognit Program, Ctr Clin Brain Sci, Edinburgh EH16 4SB, Midlothian, Scotland..
CSIC, Inst Cajal, E-28002 Madrid, Spain.;UPM, Ctr Tecnol Biomed, Madrid 28223, Spain.;ISCIII, CIBERNED, Madrid 28031, Spain..
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2018 (English)In: Neuron, ISSN 0896-6273, E-ISSN 1097-4199, Vol. 99, no 4, p. 781-+Article in journal (Refereed) Published
Abstract [en]

Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from the molecular and morphological features of a billion synapses. Each synapse subtype showed a unique anatomical distribution, and each brain region showed a distinct signature of synapse subtypes. Whole-brain synaptome cartography revealed spatial architecture from dendritic to global systems levels and previously unknown anatomical features. Synaptome mapping of circuits showed correspondence between synapse diversity and structural and functional connectomes. Behaviorally relevant patterns of neuronal activity trigger spatio-temporal postsynaptic responses sensitive to the structure of synaptome maps. Areas controlling higher cognitive function contain the greatest synapse diversity, and mutations causing cognitive disorders reorganized synaptome maps. Synaptome technology and resources have wide-ranging application in studies of the normal and diseased brain.

Place, publisher, year, edition, pages
CELL PRESS , 2018. Vol. 99, no 4, p. 781-+
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Neurosciences
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URN: urn:nbn:se:kth:diva-234601DOI: 10.1016/j.neuron.2018.07.007ISI: 000442351600015PubMedID: 30078578Scopus ID: 2-s2.0-85054006998OAI: oai:DiVA.org:kth-234601DiVA, id: diva2:1248289
Note

QC 20180914

Available from: 2018-09-14 Created: 2018-09-14 Last updated: 2018-10-16Bibliographically approved

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