Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells
Umeå University, Faculty of Science and Technology, Department of Chemistry.ORCID iD: 0000-0001-8819-2278
Show others and affiliations
2018 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 23, no 6, article id 1471Article in journal (Refereed) Published
Abstract [en]

Here and for the first time, we show that the organometallic compound [Ru(η5-C5H5)(PPh3)2Cl] (RuCp) has potential to be used as a metallodrug in anticancer therapy, and further present a new approach for the cellular delivery of the[Ru(η5-C5H5)(PPh3)2]+ fragment via coordination on the periphery of low-generation poly(alkylidenimine) dendrimers through nitrile terminal groups. Importantly, both the RuCp and the dendrimers functionalized with [Ru(η5-C5H5)(PPh3)2]+ fragments present remarkable toxicity towards a wide set of cancer cells (Caco-2, MCF-7, CAL-72, and A2780 cells), including cisplatin-resistant human ovarian carcinoma cell lines (A2780cisR cells). Also, RuCp and the prepared metallodendrimers are active against human mesenchymal stem cells (hMSCs), which are often found in the tumor microenvironment where they seem to play a role in tumor progression and drug resistance.

Place, publisher, year, edition, pages
2018. Vol. 23, no 6, article id 1471
Keywords [en]
dendrimers, nanocarriers, metallodrugs, ruthenium, platinum, cisplatin, cancer treatment, hMSCs, toxicity, nanomedicine
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-150861DOI: 10.3390/molecules23061471ISI: 000435875400232PubMedID: 29914219Scopus ID: 2-s2.0-8504894284OAI: oai:DiVA.org:umu-150861DiVA, id: diva2:1246525
Available from: 2018-09-07 Created: 2018-09-07 Last updated: 2018-09-07Bibliographically approved

Open Access in DiVA

fulltext(5396 kB)42 downloads
File information
File name FULLTEXT01.pdfFile size 5396 kBChecksum SHA-512
257254f88825a742f0e970a8e3fe9eecd5b1d81eb2ff502399a8a547d103a4dd37f72833ea55a5d5321c738171c21bbafdf83648b89a51e256f8cecd3e382696
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Figueira, JoãoRodrigues, Joao
By organisation
Department of Chemistry
In the same journal
Molecules
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 42 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 72 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf