Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer
German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.
NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
Show others and affiliations
2018 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 118, no 12, p. 1639-1647Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent.

METHODS: We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC from three consortia. Sensitivity analyses were conducted to address pleiotropy and possible confounding by body mass index.

RESULTS: Genetic risk scores for age at menarche (odds ratio per year 0.98, 95% confidence interval: 0.95-1.02) and age at menopause (odds ratio 0.98, 95% confidence interval: 0.94-1.01) were not significantly associated with CRC risk. The sensitivity analyses yielded similar results.

CONCLUSIONS: Our study does not support a causal relationship between genetic risk scores for age at menarche and age at menopause and CRC risk.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 118, no 12, p. 1639-1647
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-358536DOI: 10.1038/s41416-018-0108-8ISI: 000435644100011PubMedID: 29795306OAI: oai:DiVA.org:uu-358536DiVA, id: diva2:1243191
Funder
Swedish Research CouncilStockholm County CouncilSwedish Cancer SocietyAvailable from: 2018-08-30 Created: 2018-08-30 Last updated: 2019-11-19Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hampe, JochenLarsson, Susanna C.Wolk, Alicja
By organisation
Orthopaedics
In the same journal
British Journal of Cancer
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 13 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf