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Sleep disturbances and dementia risk: A multicenter study
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Karolinska Institutet, Sweden; Imperial College London, United Kingdom.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Jönköping University, Sweden.
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2018 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 14, no 10, p. 1235-1242Article in journal (Refereed) Published
Abstract [en]

Introduction

Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk.

Methods

Sleep disturbances were assessed in three population-based studies (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging and Dementia study [Finland]). Late-life baseline analyses (3–10 years follow-up) used all three studies (N = 1446). Baseline ages ≈ 70 years (Cardiovascular Risk Factors, Aging and Dementia, H70), and ≈84 years (Kungsholmen Project). Midlife baseline (age ≈ 50 years) analyses used Cardiovascular Risk Factors, Aging and Dementia (21 and 32 years follow-up) (N = 1407).

Results

Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02–1.50) and late-life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08–3.49) were associated with a higher dementia risk. Late-life long sleep duration (>9 hours) was also associated with an increased dementia risk (adjusted odds ratio = 3.98, 95% confidence interval = 1.87–8.48).

Discussion

Midlife insomnia and late-life terminal insomnia or long sleep duration were associated with a higher late-life dementia risk.

Place, publisher, year, edition, pages
2018. Vol. 14, no 10, p. 1235-1242
Keywords [en]
Sleep disturbances, Insomnia, Sleep duration, Dementia
National Category
Geriatrics
Research subject
Geriatrics
Identifiers
URN: urn:nbn:se:su:diva-159319DOI: 10.1016/j.jalz.2018.05.012ISI: 000446086000001OAI: oai:DiVA.org:su-159319DiVA, id: diva2:1242147
Available from: 2018-08-27 Created: 2018-08-27 Last updated: 2019-12-12Bibliographically approved

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