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Re-visiting the evolution, dispersal and epidemiology of Zika virus in Asia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway;Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;Natl Vet Inst, Dept Microbiol, Uppsala, Sweden.ORCID iD: 0000-0001-6665-7492
Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
Inst Pasteur Nouvelle Caledonie, Unite Rech Expertise Dengue & Autres Arboviroses, Noumea, New Caledonia.
Norwegian Inst Publ Hlth, Infect Dis Control & Environm Hlth, Oslo, Norway.
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2018 (English)In: EMERGING MICROBES & INFECTIONS, ISSN 2222-1751, Vol. 7, article id 79Article in journal (Refereed) Published
Abstract [en]

Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated that the introduction and dispersal of ZIKV on the Pacific islands were preceded by an extended period of relatively silent transmission in SEA, enabling the virus to expand geographically and evolve adaptively before its unanticipated introduction to immunologically naive populations on the Pacific islands and in the Americas. Our findings reveal new features of the evolution and dispersal of this intriguing virus and may benefit future disease control strategies.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 7, article id 79
National Category
Microbiology in the medical area
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URN: urn:nbn:se:uu:diva-357012DOI: 10.1038/s41426-018-0082-5ISI: 000432752700001PubMedID: 29739925OAI: oai:DiVA.org:uu-357012DiVA, id: diva2:1238204
Funder
Swedish Research Council Formas, 2015-710Available from: 2018-08-13 Created: 2018-08-13 Last updated: 2018-08-13Bibliographically approved

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