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Plasma metabolomic patterns in patients with exhaustion disorder
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
Institutet för Stressmedicin, Göteborg.
Sahlgrenska, Göteborgs Universitet.
Uppsala Universitet.
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2019 (English)In: Stress, ISSN 1025-3890, E-ISSN 1607-8888, Vol. 22, no 1, p. 17-26Article in journal (Refereed) Published
Abstract [en]

Exhaustion disorder (ED) is a stress-related disorder that often implies a great burden on the individual patient as well as on society. Previous studies have shown that ED is associated with metabolic deviations, such as lowered fasting glucose. Several mechanisms have been discussed as a plausible explanation of the lack of energy described by these patients. Metabolic processes and reduced ability to mobilize energy have been suggested as important factors. This study investigated metabolomics in 20 patients diagnosed with ED and compared them with 21 healthy controls. Plasma metabolic profiles were examined in both fasting and nonfasting (postprandial) conditions. Blood plasma samples were analyzed for metabolite content using gas chromatography mass spectrometry. A total of 62 different metabolites were simultaneously detected in each of the samples. Multivariate models indicated systematic differences between patients with ED and healthy controls in both their fasting and nonfasting plasma metabolite levels. Lysine and octadecenoic acid were more abundant and glutamine, glycine, serine and gluconic acid were less abundant in the patients across both conditions. In the present study, we comprehensively and simultaneously screen for changes in a large number of metabolites. Our results show a difference in systemic metabolites between patients with exhaustion disorder and healthy controls both in the fasting and in the postprandial states. Here, we present new potential biomarkers mirroring exhaustion disorder metabolism.

Place, publisher, year, edition, pages
Taylor & Francis, 2019. Vol. 22, no 1, p. 17-26
Keywords [en]
Clinical burnout, exhaustion disorder, metabolism, metabolomics, biomarkers, stress
National Category
Occupational Health and Environmental Health
Research subject
Occupational and Environmental Medicine
Identifiers
URN: urn:nbn:se:umu:diva-150435DOI: 10.1080/10253890.2018.1494150ISI: 000463861400003Scopus ID: 2-s2.0-85052573973OAI: oai:DiVA.org:umu-150435DiVA, id: diva2:1237268
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareAvailable from: 2018-08-08 Created: 2018-08-08 Last updated: 2019-04-26Bibliographically approved

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