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Fast and robust adaptation of organs-at-risk delineations from planning scans to match daily anatomy in pre-treatment scans for online-adaptive radiotherapy of abdominal tumors
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Erasmus MC Canc Inst, Netherlands.
Erasmus MC Canc Inst, Netherlands.
Erasmus MC Canc Inst, Netherlands.
Accuray Inc, CA 94089 USA.
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2018 (English)In: Radiotherapy and Oncology, ISSN 0167-8140, E-ISSN 1879-0887, Vol. 127, no 2, p. 332-338Article in journal (Refereed) Published
Abstract [en]

Purpose: To validate a novel deformable image registration (DIR) method for online adaptation of planning organ-at-risk (OAR) delineations to match daily anatomy during hypo-fractionated RT of abdominal tumors. Materials and methods: For 20 liver cancer patients, planning OAR delineations were adapted to daily anatomy using the DIR on corresponding repeat CTs. The DIRs accuracy was evaluated for the entire cohort by comparing adapted and expert-drawn OAR delineations using geometric (Dice Similarity Coefficient (DSC), Modified Hausdorff Distance (MHD) and Mean Surface Error (MSE)) and dosimetric (D-max and D-mean) measures. Results: For all OARs, DIR achieved average DSC, MHD and MSE of 86%, 2.1 mm, and 1.7 mm, respectively, within 20 s for each repeat CT. Compared to the baseline (translations), the average improvements ranged from 2% (in heart) to 24% (in spinal cord) in DSC, and 25% (in heart) to 44% (in right kidney) in MHD and MSE. Furthermore, differences in dose statistics (D-max, D-mean and D-2%) using delineations from an expert and the proposed DIR were found to be statistically insignificant (p amp;gt; 0.01). Conclusion: The validated DIR showed potential for online-adaptive radiotherapy of abdominal tumors as it achieved considerably high geometric and dosimetric correspondences with the expert-drawn OAR delineations, albeit in a fraction of time required by experts. (C) 2018 The Authors. Published by Elsevier B.V.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2018. Vol. 127, no 2, p. 332-338
Keywords [en]
Online adaptive radiotherapy; Cyberknife; SBRT; Image registration; Liver; Dose sparing
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-149738DOI: 10.1016/j.radonc.2018.02.014ISI: 000437107800027PubMedID: 29526492OAI: oai:DiVA.org:liu-149738DiVA, id: diva2:1233592
Note

Funding Agencies|Accuray Incorportated; Erasmus MC Cancer Institute

Available from: 2018-07-18 Created: 2018-07-18 Last updated: 2018-08-06

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