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Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma
Skane Univ Hosp, Sweden.
Skane Univ Hosp, Sweden; Lund Univ, Sweden.
Lund University, Lund, Sweden.
Lund Univ, Sweden.
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2018 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 178, no 6, p. 577-587Article in journal (Refereed) Published
Abstract [en]

Context: Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown. Objective: To determine whether there is a relationship between microstructural white matter (WM) alterations detected with diffusion tensor imaging (DTI) and cognition in adults with childhood-onset CP. Design: A cross-sectional study with a median follow-up time of 22 (6-49) years after operation. Setting: The South Medical Region of Sweden (2.5 million inhabitants). Participants: Included were 41 patients (24 women, amp;gt;= 17 years) surgically treated for childhood-onset CP between 1958-2010 and 32 controls with similar age and gender distributions. HI was found in 23 patients. Main outcome measures: Subjects performed cognitive tests and magnetic resonance imaging, and images were analyzed using DTI of uncinate fasciculus, fornix, cingulum, hippocampus and hypothalamus as well as hippocampal volumetry. Results: Right uncinate fasciculus was significantly altered (P amp;lt;= 0.01) Microstructural WM alterations in left ventral cingulum were significantly associated with worse performance in visual episodic memory, explaining approximately 50% of the variation. Alterations in dorsal cingulum were associated with worse performance in immediate, delayed recall and recognition, explaining 26-38% of the variation, and with visuospatial ability and executive function, explaining 19-29%. Patients who had smaller hippocampal volume had worse general knowledge (P = 0.028), and microstructural WM alterations in hippocampus were associated with a decline in general knowledge and episodic visual memory. Conclusions: A structure to function relationship is suggested between microstructural WM alterations in cingulum and in hippocampus with cognitive deficits in CP.

Place, publisher, year, edition, pages
BIOSCIENTIFICA LTD , 2018. Vol. 178, no 6, p. 577-587
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Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-149718DOI: 10.1530/EJE-18-0081ISI: 000437109400007PubMedID: 29599407OAI: oai:DiVA.org:liu-149718DiVA, id: diva2:1233586
Note

Funding Agencies|Swedish Childrens Cancer Foundation; Medical Faculty, Lund University, Sweden

Available from: 2018-07-18 Created: 2018-07-18 Last updated: 2018-08-06

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Ekman, Bertil
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Endocrinology
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