Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis
Shanghai Jiao Tong Univ, Peoples Republic of China.
Shanghai Jiao Tong Univ, Peoples Republic of China.
Southwest Univ, Peoples Republic of China.
Chinese Natl Human Genome Ctr Shanghai, Peoples Republic of China.
Show others and affiliations
2018 (English)In: Molecular Plant, ISSN 1674-2052, E-ISSN 1752-9867, Vol. 11, no 6, p. 776-788Article in journal (Refereed) Published
Abstract [en]

Artemisia annua, commonly known as sweet wormwood or Qinghao, is a shrub native to China and has long been used for medicinal purposes. A. annua is now cultivated globally as the only natural source of a potent anti-malarial compound, artemisinin. Here, we report a high-quality draft assembly of the 1.74-gigabase genome of A. annua, which is highly heterozygous, rich in repetitive sequences, and contains 63 226 protein-coding genes, one of the largest numbers among the sequenced plant species. We found that, as one of a few sequenced genomes in the Asteraceae, the A. annua genome contains a large number of genes specific to this large angiosperm clade. Notably, the expansion and functional diversification of genes encoding enzymes involved in terpene biosynthesis are consistent with the evolution of the artemisinin biosynthetic pathway. We further revealed by transcriptome profiling that A. annua has evolved the sophisticated transcriptional regulatory networks underlying artemisinin biosynthesis. Based on comprehensive genomic and transcriptomic analyses we generated transgenic A. annua lines producing high levels of artemisinin, which are now ready for large-scale production and thereby will help meet the challenge of increasing global demand of artemisinin.

Place, publisher, year, edition, pages
Cell Press , 2018. Vol. 11, no 6, p. 776-788
Keywords [en]
Artemisia annua, artemisinin, genome, evolution, transcriptome, metabolic engineering
National Category
Biochemistry and Molecular Biology
Research subject
Chemistry, Biochemistry
Identifiers
URN: urn:nbn:se:lnu:diva-76879DOI: 10.1016/j.molp.2018.03.015ISI: 000434429000003PubMedID: 29703587Scopus ID: 2-s2.0-85045897546OAI: oai:DiVA.org:lnu-76879DiVA, id: diva2:1233348
Available from: 2018-07-17 Created: 2018-07-17 Last updated: 2019-08-29Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Brodelius, Peter E.Tang, Kexuan
By organisation
Department of Chemistry and Biomedical Sciences
In the same journal
Molecular Plant
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 23 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf