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PDGF-C and PDGF-D signaling in vascular diseases and animal models
Karolinska Inst, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
2018 (English)In: Molecular Aspects of Medicine, ISSN 0098-2997, E-ISSN 1872-9452, Vol. 62Article, review/survey (Refereed) Published
Abstract [en]

Members of the platelet-derived growth factor (PDGF) family are well known to be involved in different pathological conditions. The cellular and molecular mechanisms induced by the PDGF signaling have been well studied. Nevertheless, there is much more to discover about their functions and some important questions to be answered. This review summarizes the known roles of two of the PDGFs, PDGF-C and PDGF-D, in vascular diseases. There are clear implications for these growth factors in several vascular diseases, such as atherosclerosis and stroke. The PDGF receptors are broadly expressed in the cardiovascular system in cells such as fibroblasts, smooth muscle cells and pericytes. Altered expression of the receptors and the ligands have been found in various cardiovascular diseases and current studies have shown important implications of PDGF-C and PDGF-D signaling in fibrosis, neovascularization, atherosclerosis and restenosis. (C) 2018 The Authors. Published by Elsevier Ltd.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2018. Vol. 62
Keywords [en]
Aneurysm; Atherosclerosis; Growth factor; Myocardial infarction; Smooth muscle cells
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-149334DOI: 10.1016/j.mam.2018.01.005ISI: 000435085900001PubMedID: 29410092OAI: oai:DiVA.org:liu-149334DiVA, id: diva2:1229848
Available from: 2018-07-02 Created: 2018-07-02 Last updated: 2018-08-02

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