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A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
Karolinska Inst, Ludwig Inst Canc Res, Dept Cell & Mol Biol, Nobels Vag 3, S-17177 Stockholm, Sweden.
Karolinska Inst, Ludwig Inst Canc Res, Dept Cell & Mol Biol, Nobels Vag 3, S-17177 Stockholm, Sweden.
Karolinska Inst, Ludwig Inst Canc Res, Dept Cell & Mol Biol, Nobels Vag 3, S-17177 Stockholm, Sweden.
Karolinska Inst, Ludwig Inst Canc Res, Dept Cell & Mol Biol, Nobels Vag 3, S-17177 Stockholm, Sweden.
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2018 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, article id 1226Article in journal (Refereed) Published
Abstract [en]

The brain is composed of hundreds of different neuronal subtypes, which largely retain their identity throughout the lifespan of the organism. The mechanisms governing this stability are not fully understood, partly due to the diversity and limited size of clinically relevant neuronal populations, which constitute a technical challenge for analysis. Here, using a strategy that allows for ChIP-seq combined with RNA-seq in small neuronal populations in vivo, we present a comparative analysis of permissive and repressive histone modifications in adult midbrain dopaminergic neurons, raphe nuclei serotonergic neurons, and embryonic neural progenitors. Furthermore, we utilize the map generated by our analysis to show that the transcriptional response of midbrain dopaminergic neurons following 6-OHDA or methamphetamine injection is characterized by increased expression of genes with promoters dually marked by H3K4me3/H3K27me3. Our study provides an in vivo genome-wide analysis of permissive/repressive histone modifications coupled to gene expression in these rare neuronal subtypes.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 9, article id 1226
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Neurosciences
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URN: urn:nbn:se:uu:diva-354352DOI: 10.1038/s41467-018-03538-9ISI: 000428237700005PubMedID: 29581424OAI: oai:DiVA.org:uu-354352DiVA, id: diva2:1227956
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Knut and Alice Wallenberg FoundationSwedish Research CouncilAvailable from: 2018-06-27 Created: 2018-06-27 Last updated: 2018-06-27Bibliographically approved

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