Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effects of GIP on regional blood flow during normoglycemia and hyperglycemia in anesthetized rats
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Lund Univ, Diabet Ctr, Dept Clin Sci, Malmo, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Lund Univ, Diabet Ctr, Dept Clin Sci, Malmo, Sweden.
Show others and affiliations
2018 (English)In: Physiological Reports, E-ISSN 2051-817X, Vol. 6, no 8, article id e13685Article in journal (Refereed) Published
Abstract [en]

The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion, and affects -cell turnover. This study aimed at evaluating if some of the beneficial effects of GIP on glucose homeostasis can be explained by modulation of islet blood flow. Anesthetized Sprague-Dawley rats were infused intravenously with different doses of GIP (10, 20, or 60ng/kg*min) for 30min. Subsequent organ blood flow measurements were performed with microspheres. In separate animals, islets were perfused exvivo with GIP (10(-6)-10(-12)mol/L) during normo- and hyperglycemia and arteriolar responsiveness was recorded. The highest dose of GIP potentiated insulin secretion during hyperglycemia, but had no effect in normoglycemic rats. The highest GIP concentration decreased blood perfusion of whole pancreas, pancreatic islets, duodenum, colon, liver and kidneys. The decrease in blood flow was unaffected by ganglion blockade or adenosine receptor inhibition. In contrast to this, in single perfused islets GIP induced a dose-dependent arteriolar dilation. Thus, high doses of GIP exert a direct dilatory effect on islet arterioles in isolated islets, but induce a generalized vasoconstriction in splanchnic organs, including the whole pancreas and islets, invivo. The latter effect is unlikely to be mediated by adenosine, the autonomic nervous system, or endothelial mediators.

Place, publisher, year, edition, pages
2018. Vol. 6, no 8, article id e13685
Keywords [en]
Glucose-dependent insulinotropic peptide, incretin hormones, Islet blood flow, pancreatic islets, splanchnic blood flow
National Category
Physiology Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-354242DOI: 10.14814/phy2.13685ISI: 000430922300017PubMedID: 29673130OAI: oai:DiVA.org:uu-354242DiVA, id: diva2:1221005
Funder
Swedish Research Council, 521-2011-3777Swedish Research Council, 2008-4216Swedish Research Council, 521-2012-2119Available from: 2018-06-19 Created: 2018-06-19 Last updated: 2018-06-19Bibliographically approved

Open Access in DiVA

fulltext(1975 kB)7 downloads
File information
File name FULLTEXT01.pdfFile size 1975 kBChecksum SHA-512
8db29e730457038cacea518d67bac1665973f481554941e3f7bf97d83ee776b6d5ab4d2f982b89830af04cab7be81590bb8b0f154f7b90ad7800c817f5040e5d
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Gao, XiangSandberg, MonicaJansson, Leif
By organisation
Department of Medical Cell Biology
In the same journal
Physiological Reports
PhysiologyEndocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 7 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 25 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf