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A rheological study of hyaluronan and sodium hydroxide at different concentrations
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
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2018 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

This thesis examines how the rheological properties change depending on the composition of hyaluronan, HA and sodium hydroxide, NaOH. This was performed to see if there was any relationship between the rheological properties of a sample depending on different compositions of HA and NaOH. Moreover, the fluidity of the samples was studied by investigating . Five concentrations of HA (11, 18, 20, 25, 33 wt%) were investigated with six concentrations of NaOH (0, 1, 2, 4, 6, 8 wt%). Rheology was used to determine rheological properties of the composition and the rheometric data was obtained from three different measurements: time sweep, frequency sweep and amplitude sweep. G', G'' andwere investigated but no clear correlation was found. However, some patterns were detected for frequency sweep and amplitude sweep. The graphs generally followed the same shape and the compositions with 11% HA generally had the lowest G' and G'' values. Additionally, the majority of the samples, that could be measured, could be defined as fluids, due to  being higher than 1.

Place, publisher, year, edition, pages
2018.
Series
TVE ; TVE-K 18 004
Keywords [en]
hyaluronan, hyaluronic acid, sodium hydroxide, rheology, fluid, elastic modulus, loss modulus
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-354045OAI: oai:DiVA.org:uu-354045DiVA, id: diva2:1220435
External cooperation
Galderma
Educational program
Master Programme in Chemical Engineering
Supervisors
Examiners
Available from: 2018-06-20 Created: 2018-06-18 Last updated: 2018-06-20Bibliographically approved

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