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The Impact of Compressive and Cyclic Loading Frequency on Longitudinal Growth, Given a Constant Amplitude
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH).
2018 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Frekvenspåverkan av cyklisk kompressionslast på longitudinell tillväxt, givet en kontant amplitud (Swedish)
Abstract [en]

Mechanical stress exerted on long bones stimulate ossification and it has been shown that the mechanical variable frequency promotes osteogenesis. This ex-vivo study aimed to investigate how compressive and cyclic loading frequency impacts longitudinal growth of long bones. Three separate experiments were performed utilizing fetal Sprague-Dawley rat bones as experimental model. In the first two trials metatarsals where used while tibias were tested in the third trial. The bones were loaded once with a material testing system, cultured in an incubator and had their length measured on several occasions throughout their growth period. Loading protocol and days of length measurement differed between the trials. The first trial failed, since all of the control bones decreased in length in relation to the day of loading, while they should at least have grown 30% on the fifth day after loading. The results obtained from the second trial indicate that the frequency 0.4 Hz has a great impact on longitudinal growth, with a length increase of 50%-60% in relation to the day of loading. A conclusion regarding the other frequencies studied could not be made due to high spread of length alteration data. The tibias from the last trial did not show any significant results. Moreover, it was concluded that compressive and cyclic loading do promote longitudinal growth, despite the great variation in length alteration for most of the bones, including the control bones. The findings of this study could serve as a foundation for a research study further investigating the relation between frequency and longitudinal growth.

Place, publisher, year, edition, pages
2018. , p. 54
Series
TRITA-CBH-GRU ; 2018:76
Keywords [en]
Biotechnology, Biomechanics, Mechanical stress, Frequency, Longitudinal growth
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-230806OAI: oai:DiVA.org:kth-230806DiVA, id: diva2:1219638
Subject / course
Medical Engineering
Educational program
Master of Science in Engineering - Medical Engineering
Supervisors
Examiners
Available from: 2018-06-25 Created: 2018-06-17 Last updated: 2018-06-25Bibliographically approved

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Citation style
  • apa
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