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Ethanol, ethyl glucuronide, and ethyl sulfate kinetics after multiple ethanol intakes: A study of ethanol consumption to better determine the latest intake of alcoholin hip flask defence cases
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Rättsmedicinalverket.
2018 (English)Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

The hip-flask defence is a common claim in drunkdrinking cases. In Sweden and Norway two different models are used to determinethese cases. In Sweden one blood and two urine samples taken 60 minutes apartare used for analysis. In Norway two blood samples taken 30 minutes apart areused. Sweden focuses on the rise or fall of alcohol concentration in urine(UAC), and the ratio between UAC and blood alcohol concentrations (BAC). Norwayfocuses on the rise or fall of the alcohol metabolite ethylglucuronide (EtG) and the ratio between BAC and EtG. The aim of this study wasto test the models for multiple intakes and with different alcoholic beverages.Thirtyfive participants ingested two doses, first0.51 g/kg of beer and later either 0.25, 0.51 or 0.85 g/kg of beer, wine orvodka. Blood and urine samples were obtained before and after alcoholingestion. Alcohol was measured by GC-HS, and the alcohol metabolite byUPLC-MS/MS. The results showed that there are kineticdifferences between single and repeated intakes, that there are no significantdifferences in kinetics from different alcoholic beverages and thatthe Norwegian model appears to be the stronger one in hip-flask determination.

Place, publisher, year, edition, pages
2018. , p. 44
Keywords [en]
Ethanol, ethyl glucuronide, ethyl sulfate, kinetics, multiple intakes, hip flask defence, GC-FID, UPLC-MS/MS
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-148546ISRN: LITH-IFM-G-EX--18/3504--SEOAI: oai:DiVA.org:liu-148546DiVA, id: diva2:1217608
Subject / course
Chemistry
Presentation
2018-05-30, Linköping, 11:06 (Swedish)
Supervisors
Examiners
Available from: 2018-08-31 Created: 2018-06-13 Last updated: 2018-08-31Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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Output format
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