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Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
INSERM, UMR 946, Genet Variat & Human Dis Unit, Paris, France.;Univ Paris Diderot, Univ Sorbonne Paris Cite, Inst Univ Hematol, Paris, France..ORCID iD: 0000-0001-8361-0936
INSERM, UMR 946, Genet Variat & Human Dis Unit, Paris, France.;Univ Paris Diderot, Univ Sorbonne Paris Cite, Inst Univ Hematol, Paris, France..
Univ Colorado, Colorado Ctr Personalized Med, Div Biomed Informat & Personalized Med, Denver, CO 80202 USA..
Natl Heart & Lung Inst, Sect Genom Med, London, England..
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2018 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 50, no 1, p. 42-+Article in journal (Refereed) Published
Abstract [en]

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

Place, publisher, year, edition, pages
2018. Vol. 50, no 1, p. 42-+
National Category
Genetics
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URN: urn:nbn:se:uu:diva-343883DOI: 10.1038/s41588-017-0014-7ISI: 000423157400008PubMedID: 29273806OAI: oai:DiVA.org:uu-343883DiVA, id: diva2:1191091
Funder
NIH (National Institute of Health), U01 HL130114; RC2 HL101651Available from: 2018-03-16 Created: 2018-03-16 Last updated: 2018-03-16Bibliographically approved

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