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Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice
Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden..
Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden..
Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden..
Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden..
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2017 (English)In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 8, article id 1699Article in journal (Refereed) Published
Abstract [en]

The intestinal microbiota influences immune maturation during childhood, and is implicated in early-life allergy development. However, to directly study intestinal microbes and gut immune responses in infants is difficult. To investigate how different types of early-life gut microbiota affect immune development, we collected fecal samples from children with different allergic heredity (AH) and inoculated germ-free mice. Immune responses and microbiota composition were evaluated in the offspring of these mice. Microbial composition in the small intestine, the cecum and the colon were determined by 16S rRNA sequencing. The intestinal microbiota differed markedly between the groups of mice, but only exposure to microbiota associated with AH and known future allergy in children resulted in a T helper 17 (Th17)-signature, both systemically and in the gut mucosa in the mouse offspring. These Th17 responses could be signs of a particular microbiota and a shift in immune development, ultimately resulting in an increased risk of allergy.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2017. Vol. 8, article id 1699
Keywords [en]
infant microbiota, allergic heredity, immune development, germ-free, T helper 17-responsesIN
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-343555DOI: 10.3389/fimmu.2017.01699ISI: 000416803000001OAI: oai:DiVA.org:uu-343555DiVA, id: diva2:1187236
Funder
Swedish Research Council, 2013-02904Swedish Heart Lung FoundationTorsten Söderbergs stiftelseStiftelsen Olle Engkvist ByggmästareCarl Tryggers foundation Swedish Research Council, 2016-04449Available from: 2018-03-02 Created: 2018-03-02 Last updated: 2018-03-02Bibliographically approved

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Huseby, Douglas L.Hughes, Diarmaid
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