Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer
Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Internal Med, Stockholm.
Stockholms Sjukhem Fdn, Palliat Care Serv, Stockholm; Karolinska Inst, Dept Oncol Pathol, Stockholm.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.ORCID iD: 0000-0002-6381-2968
Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Internal Med, Stockholm.
Show others and affiliations
2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 1, article id e0191231Article in journal (Refereed) Published
Abstract [en]

Citrullinated histone H3 (H3Cit) is a central player in the neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs). NETs have been shown to elicit harmful effects on the host, and were recently proposed to promote tumor progression and spread. Here we report significant elevations of plasma H3Cit in patients with advanced cancer compared with age-matched healthy individuals. These elevations were specific to cancer patients as no increase was observed in severely ill and hospitalized patients with a higher non-malignant comorbidity. The analysis of neutrophils from cancer patients showed a higher proportion of neutrophils positive for intracellular H3Cit compared to severely ill patients. Moreover, the presence of plasma H3Cit in cancer patients strongly correlated with neutrophil activation markers neutrophil elastase (NE) and myeloperoxidase (MPO), and the inflammatory cytokines interleukin-6 and -8, known to induce NETosis. In addition, we show that high levels of circulating H3Cit strongly predicted poor clinical outcome in our cohort of cancer patients with a 2-fold increased risk for short-term mortality. Our results also corroborate the association of NE, interleukin-6 and -8 with poor clinical outcome. Taken together, our results are the first to unveil H3Cit as a potential diagnostic and prognostic blood marker associated with an exacerbated inflammatory response in patients with advanced cancer.

Place, publisher, year, edition, pages
2018. Vol. 13, no 1, article id e0191231
National Category
Cancer and Oncology Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:uu:diva-343379DOI: 10.1371/journal.pone.0191231ISI: 000419952400133PubMedID: 29324871OAI: oai:DiVA.org:uu-343379DiVA, id: diva2:1186164
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationRagnar Söderbergs stiftelseAvailable from: 2018-02-27 Created: 2018-02-27 Last updated: 2018-03-02Bibliographically approved

Open Access in DiVA

fulltext(6736 kB)6 downloads
File information
File name FULLTEXT01.pdfFile size 6736 kBChecksum SHA-512
da10835263621c37bb9d45da35a2949b8b43d96845562b7d716fb208a345329edb8d2920e9913c7604aa6e55a0366ff8d4b326ba28458808ca7805c7b9231006
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Seignez, CedricPhillipson, Mia
By organisation
Integrative Physiology
In the same journal
PLoS ONE
Cancer and OncologyGastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar
Total: 6 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 60 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf